SCHEMBL21546482

SCHEMBL21546482

N#Cc1cccc(-c2cc(-n3c4ccccc4c4cc(-c5ccccc5)ccc43)c(C#N)c(-n3c4ccc(-c5ccccc5)cc4c4cc(-c5ccc6c(c5)c5ccc(-c7ccccc7)cc5n6-c5cc(-c6cccc(C#N)c6)cc(-n6c7ccccc7c7ccc(-c8ccccc8)cc76)c5C#N)ccc43)c2)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 3/20 0.38
ADORA1 P30542 3/20 0.38
ALDH1A3 P47895 1/20 0.37
GRIA2 P42262 1/20 0.37
GRIA4 P48058 1/20 0.37
MAP4K4 O95819 1/20 0.36
PTPN5 P54829 1/20 0.36
XDH P47989 1/20 0.36
SLC22A12 Q96S37 1/20 0.36
GABRA1 P14867 1/20 0.36
GABRG2 P18507 1/20 0.36
GABRB3 P28472 1/20 0.36
GABRA5 P31644 1/20 0.36
GABRA3 P34903 1/20 0.36
ADORA2B P29275 2/20 0.36
ALDH1A1 P00352 5/20 0.35
CYP1A2 P05177 5/20 0.35
CYP3A4 P08684 4/20 0.35
CLK4 Q9HAZ1 4/20 0.35
LMNA P02545 3/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21546928 0.96 ADORA2A (0.40) ADORA2AADORA1ALDH1A3GRIA2GRIA4
SCHEMBL22760653 0.96 ADORA2A (0.35) ADORA2AADORA1ALDH1A3GRIA2GRIA4
SCHEMBL21547017 0.95 MAP4K4 (0.36) ADORA2AADORA1ALDH1A3GRIA2GRIA4
SCHEMBL22760703 0.94 MAP4K4 (0.40) ADORA2AADORA1ALDH1A3GRIA2GRIA4
SCHEMBL22760655 0.94 ADORA2A (0.34) ADORA2AADORA1ALDH1A3GRIA2GRIA4
SCHEMBL21546768 0.93 PTGER4 (0.38) ADORA2AADORA1ALDH1A3GRIA2GRIA4
SCHEMBL21546441 0.93 ADORA1 (0.42) ADORA2AADORA1ALDH1A3GRIA2GRIA4
SCHEMBL21546742 0.93 ADORA1 (0.42) ADORA2AADORA1ALDH1A3GRIA2GRIA4
SCHEMBL22760894 0.92 MAP4K4 (0.38) ADORA2AADORA1ALDH1A3GRIA2GRIA4
SCHEMBL21546840 0.92 ADORA2A (0.37) ADORA2AADORA1ALDH1A3GRIA2GRIA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3478793-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2019-11-06 EP disclosed