SCHEMBL21547017

SCHEMBL21547017

N#Cc1cccc(-c2cc(-n3c4ccccc4c4cc(-c5cccc(C#N)c5)ccc43)c(C#N)c(-n3c4ccc(-c5cccc(C#N)c5)cc4c4cc(-c5cc(C#N)cc(-c6ccc7c8ccccc8n(-c8cc(-c9cccc(C#N)c9)cc(-n9c%10ccccc%10c%10ccc(-c%11cccc(C#N)c%11)cc%109)c8C#N)c7c6)c5)ccc43)c2)c1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAP4K4 O95819 1/20 0.36
ADORA2A P29274 3/20 0.35
ADORA1 P30542 2/20 0.35
ALDH1A3 P47895 1/20 0.35
PGR P06401 2/20 0.34
CYP1A2 P05177 4/20 0.34
CYP3A4 P08684 4/20 0.34
CLK4 Q9HAZ1 4/20 0.34
ALDH1A1 P00352 3/20 0.34
PLG P00747 1/20 0.34
PLAU P00749 1/20 0.34
PTPN5 P54829 1/20 0.34
USP2 O75604 2/20 0.33
HIF1A Q16665 2/20 0.33
XDH P47989 1/20 0.33
SLC22A12 Q96S37 1/20 0.33
PTGER4 P35408 1/20 0.33
ADORA2B P29275 1/20 0.33
LMNA P02545 1/20 0.33
TP53 P04637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21546482 0.95 ADORA2A (0.38) MAP4K4ADORA2AADORA1ALDH1A3PGR
SCHEMBL22760894 0.94 MAP4K4 (0.38) MAP4K4ADORA2AADORA1ALDH1A3PGR
SCHEMBL21546840 0.94 ADORA2A (0.37) MAP4K4ADORA2AADORA1ALDH1A3PGR
SCHEMBL22760703 0.94 MAP4K4 (0.40) MAP4K4ADORA2AADORA1ALDH1A3PGR
SCHEMBL20617063 0.92 PTPN5 (0.38) MAP4K4ADORA2AADORA1ALDH1A3PGR
SCHEMBL21546928 0.92 ADORA2A (0.40) MAP4K4ADORA2AADORA1ALDH1A3PGR
SCHEMBL22760653 0.91 ADORA2A (0.35) MAP4K4ADORA2AADORA1ALDH1A3PGR
SCHEMBL19903455 0.91 PTPN5 (0.38) MAP4K4ADORA2AADORA1ALDH1A3PGR
SCHEMBL21546768 0.91 PTGER4 (0.38) MAP4K4ADORA2AADORA1ALDH1A3PGR
SCHEMBL21546684 0.89 MAP4K4 (0.39) MAP4K4ADORA2AADORA1ALDH1A3PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3478793-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2019-11-06 EP disclosed