SCHEMBL21546650

SCHEMBL21546650

N#Cc1cccc(-c2cc(-n3c4ccccc4c4ccc(-c5cc(C(F)(F)F)cc(C(F)(F)F)c5)cc43)c(C#N)cc2-n2c3ccccc3c3ccc(-c4cc(C(F)(F)F)cc(C(F)(F)F)c4)cc32)c1

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PTPN5 P54829 1/20 0.38
ENPP1 P22413 1/20 0.37
PDK2 Q15119 1/20 0.36
GRIN1 Q05586 3/20 0.36
GRIN2B Q13224 3/20 0.36
CETP P11597 1/20 0.35
RXRA P19793 1/20 0.35
RXRG P48443 1/20 0.35
PTGDR2 Q9Y5Y4 1/20 0.34
MAT2A P31153 1/20 0.34
TRPA1 O75762 1/20 0.33
ALPL P05186 1/20 0.33
ALPI P09923 1/20 0.33
ALDH1A3 P47895 1/20 0.33
KDM4E B2RXH2 1/20 0.32
SYK P43405 1/20 0.32
PGR P06401 1/20 0.32
AR P10275 1/20 0.32
XDH P47989 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22760612 0.99 PTPN5 (0.38) PTPN5ENPP1PDK2GRIN1GRIN2B
SCHEMBL19903681 0.97 PTPN5 (0.39) PTPN5ENPP1PDK2GRIN1GRIN2B
SCHEMBL21546651 0.97 ENPP1 (0.39) PTPN5ENPP1PDK2GRIN1GRIN2B
SCHEMBL22822141 0.95 PTPN5 (0.39) PTPN5ENPP1PDK2GRIN1GRIN2B
SCHEMBL22760613 0.94 PTPN5 (0.38) PTPN5ENPP1PDK2GRIN1GRIN2B
SCHEMBL22761121 0.94 PTPN5 (0.38) PTPN5ENPP1PDK2GRIN1GRIN2B
SCHEMBL21440721 0.94 PTPN5 (0.38) PTPN5ENPP1PDK2GRIN1GRIN2B
SCHEMBL20617037 0.93 RXRA (0.39) PTPN5GRIN1GRIN2BRXRARXRG
SCHEMBL19912453 0.92 GRIN1 (0.41) PTPN5ENPP1PDK2GRIN1GRIN2B
SCHEMBL19903607 0.92 RXRA (0.38) PTPN5GRIN1GRIN2BRXRARXRG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3478793-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2019-11-06 EP disclosed