SCHEMBL21546961

SCHEMBL21546961

N#Cc1cccc(-c2cc(-n3c4ccccc4c4ccc(C(F)(F)F)cc43)c(C(F)(F)F)c(-n3c4ccccc4c4ccc(C(F)(F)F)cc43)c2)c1

nearest known ligand 0.43

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 2/20 0.43
PTPN5 P54829 1/20 0.43
MAT2A P31153 2/20 0.40
PTGDR2 Q9Y5Y4 1/20 0.38
GRIN1 Q05586 3/20 0.38
GRIN2B Q13224 3/20 0.38
TRPA1 O75762 1/20 0.37
PDK2 Q15119 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.35
MRGPRX4 Q96LA9 1/20 0.35
GRM5 P41594 1/20 0.35
ENPP1 P22413 1/20 0.35
CETP P11597 1/20 0.35
SYK P43405 1/20 0.34
ADORA2A P29274 1/20 0.33
CCR6 P51684 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22760794 0.97 KIF11 (0.41) KIF11PTPN5MAT2APTGDR2GRIN1
SCHEMBL21546963 0.95 PTPN5 (0.43) KIF11PTPN5MAT2APTGDR2GRIN1
SCHEMBL21546962 0.93 PTPN5 (0.43) KIF11PTPN5MAT2APTGDR2GRIN1
SCHEMBL21547089 0.93 PTPN5 (0.41) KIF11PTPN5MAT2APTGDR2GRIN1
SCHEMBL21546777 0.92 KIF11 (0.42) KIF11PTPN5MAT2APTGDR2GRIN1
SCHEMBL22760793 0.92 PTPN5 (0.40) PTPN5MAT2APDK2GRM5ENPP1
SCHEMBL22761171 0.92 PTPN5 (0.43) PTPN5GRIN1GRIN2BPDK2GRM5
SCHEMBL21547137 0.91 PTPN5 (0.41) KIF11PTPN5MAT2APTGDR2GRIN1
SCHEMBL22761221 0.90 PTPN5 (0.39) PTPN5MAT2AGRIN1GRIN2BPDK2
SCHEMBL21546526 0.90 PTPN5 (0.41) PTPN5GRIN1GRIN2BPDK2ENPP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3478793-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2019-11-06 EP disclosed