Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP7 | Q9UHL4 | 8/20 | 0.63 |
| ▸ | DPP4 | P27487 | 8/20 | 0.55 |
| ▸ | DPP8 | Q6V1X1 | 7/20 | 0.45 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.41 |
| ▸ | ARG1 | P05089 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5789549 | 0.85 | DPP7 (0.66) | DPP7DPP4DPP8DPP9ARG1 | |
| SCHEMBL5789775 | 0.85 | DPP7 (0.66) | DPP7DPP4DPP8DPP9ARG1 | |
| SCHEMBL3066433 | 0.83 | DPP4 (0.51) | DPP7DPP4DPP8DPP9 | |
| SCHEMBL17152480 | 0.82 | DPP4 (0.61) | DPP7DPP4DPP8DPP9ARG1 | |
| SCHEMBL12352126 | 0.76 | DPP7 (0.76) | DPP7DPP4DPP8DPP9 | |
| SCHEMBL15247212 | 0.75 | DPP9 (0.40) | DPP7DPP4DPP8DPP9ARG1 | |
| SCHEMBL14655996 | 0.75 | DPP4 (0.66) | DPP7DPP4DPP8DPP9 | |
| SCHEMBL20210138 | 0.75 | DPP9 (0.45) | DPP7DPP4DPP8DPP9ARG1 | |
| SCHEMBL6052747 | 0.73 | HDAC8 (0.59) | DPP7DPP4DPP8DPP9 | |
| SCHEMBL4095232 | 0.73 | HDAC8 (0.59) | DPP7DPP4DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191113-B1 | MACROCYCLIC INHIBITORS OF THE PD-1/PD-L1 AND CD80 (B7-1)/PD-L1 PROTEIN/PROTEIN INTERACTIONS | BRISTOL MYERS SQUIBB CO (US) | 2019-11-06 | — | — | EP | disclosed |