Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21526074 | 0.91 | SMN1; SMN2 (0.46) | HTTSMN1; SMN2KDM4CMAPTALDH1A1 | |
| SCHEMBL20356703 | 0.85 | SMN1; SMN2 (0.48) | HTTSMN1; SMN2MAPTTP53GAA | |
| SCHEMBL21526065 | 0.80 | HTT (0.45) | HTTSMN1; SMN2KDM4CHPGDKMT2A | |
| SCHEMBL20356667 | 0.78 | SMN1; SMN2 (0.54) | HTTSMN1; SMN2KDM4CKMT2A | |
| SCHEMBL21526053 | 0.75 | SMN1; SMN2 (0.50) | HTTSMN1; SMN2KDM4CKMT2A | |
| SCHEMBL20356760 | 0.75 | GAA (0.38) | HTTSMN1; SMN2MAPTPOLBTP53 | |
| SCHEMBL21548933 | 0.73 | SMN1; SMN2 (0.61) | HTTSMN1; SMN2KDM4CMAPTALDH1A1 | |
| SCHEMBL20356706 | 0.73 | SMN1; SMN2 (0.45) | HTTSMN1; SMN2MAPTPOLBTP53 | |
| SCHEMBL21526092 | 0.72 | SMN1; SMN2 (0.56) | HTTSMN1; SMN2MAPTTP53GAA | |
| SCHEMBL20356705 | 0.72 | MAPT (0.40) | HTTSMN1; SMN2MAPTTP53GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3564216-B1 | PYRIMIDINE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2021-10-27 | — | — | EP | disclosed |
| EP-3564216-A1 | PYRIMIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2019-11-06 | — | — | EP | disclosed |