Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | SLC6A7 | Q99884 | 2/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28551924 | 1.00 | GPR119 (0.49) | GPR119HDAC1MAP4K4SUV39H2CHRM4 | |
| SCHEMBL21551584 | 0.89 | GPR119 (0.46) | GPR119HDAC1MAP4K4SUV39H2SLC6A7 | |
| SCHEMBL21551582 | 0.89 | GPR119 (0.46) | GPR119HDAC1MAP4K4SUV39H2SLC6A7 | |
| SCHEMBL21551176 | 0.88 | CHRM4 (0.42) | GPR119CHRM4CHRM2CHRM1SLC6A7 | |
| SCHEMBL28551699 | 0.88 | CHRM4 (0.42) | GPR119CHRM4CHRM2CHRM1SLC6A7 | |
| SCHEMBL29891316 | 0.87 | GPR119 (0.48) | GPR119 | |
| SCHEMBL21553761 | 0.87 | GPR119 (0.48) | GPR119 | |
| SCHEMBL29890912 | 0.83 | GPR119 (0.46) | GPR119SUV39H2 | |
| SCHEMBL21551729 | 0.83 | GPR119 (0.46) | GPR119SUV39H2 | |
| SCHEMBL31713165 | 0.83 | GPR119 (0.58) | GPR119HDAC1MAP4K4SUV39H2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112384509-B | Furin inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2024-04-30 | — | — | CN | disclosed |
| EP-3790871-B1 | FURIN INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2024-01-24 | — | — | EP | disclosed |
| EP-3790871-A1 | FURIN INHIBITORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2021-03-17 | — | — | EP | disclosed |
| CN-112384509-A | Furin inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2021-02-19 | — | — | CN | disclosed |
| WO-2019215341-A1 | FURIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-11-14 | — | — | WO | disclosed |
| WO-2019215341-A1 | FURIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-11-14 | — | — | WO | disclosed |