Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 8/20 | 0.50 |
| ▸ | MERTK | Q12866 | 7/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | TYRO3 | Q06418 | 6/20 | 0.44 |
| ▸ | FLT3 | P36888 | 5/20 | 0.44 |
| ▸ | GAS6 | Q14393 | 5/20 | 0.44 |
| ▸ | AXL | P30530 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15249748 | 0.87 | SYK (0.51) | SYKMERTKPDE4BPPARGMEN1 | |
| SCHEMBL15249749 | 0.86 | SYK (0.65) | SYK | |
| SCHEMBL26931049 | 0.83 | MERTK (0.57) | SYKMERTKTYRO3FLT3GAS6 | |
| SCHEMBL26931042 | 0.83 | MERTK (0.57) | SYKMERTKTYRO3FLT3GAS6 | |
| SCHEMBL26161013 | 0.82 | SYK (0.49) | SYKMERTKPPARGMEN1GABBR2 | |
| SCHEMBL31360665 | 0.82 | MEN1 (0.49) | SYKMERTKALDH1A1MEN1GABBR2 | |
| SCHEMBL1226594 | 0.82 | MEN1 (0.49) | SYKMERTKPPARGMEN1GABBR2 | |
| SCHEMBL2622287 | 0.82 | MEN1 (0.49) | SYKMERTKALDH1A1MEN1GABBR2 | |
| SCHEMBL16824904 | 0.81 | RXFP1 (0.48) | SYKMERTKPDE4BALDH1A1MEN1 | |
| SCHEMBL22553618 | 0.81 | SYK (0.46) | SYKMERTKPDE4BTYRO3FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10851087-B2 | Synthesis of cerdulatinib | PORTOLA PHARMACEUTICALS, INC. (US) | 2020-12-01 | — | — | US | disclosed |
| US-20190337930-A1 | SYNTHESIS OF CERDULATINIB | ALEXION PHARMACEUTICALS, INC. | 2019-11-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190337930-A1 | SYNTHESIS OF CERDULATINIB | JAK2, DCK, CERS2 | SYK 644/4885MERTK 1461/4885PDE4B 2048/4885 |
| US-10851087-B2 | Synthesis of cerdulatinib | JAK2, DCK, CERS2 | SYK 644/4885MERTK 1461/4885PDE4B 2048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.