Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of 2-Pyrrolidone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.71 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.61 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Pyrrolidone SCHEMBL27605240 | 0.98 | OR51E2 (0.68) | OR51E2CRBNFKBP5KDM4EGAA | |
| 2-Pyrrolidone SCHEMBL27544296 | 0.96 | OR51E2 (0.65) | OR51E2CRBNFKBP5KDM4EGAA | |
| Acetic Acid SCHEMBL7696253 | 0.93 | CRBN (0.73) | OR51E2CRBNFKBP5KDM4EGAA | |
| 2-Pyrrolidone SCHEMBL17698402 | 0.93 | OR51E2 (0.75) | OR51E2CRBNFKBP5KDM4EGAA | |
| 2-Pyrrolidone SCHEMBL28311398 | 0.92 | OR51E2 (0.60) | OR51E2CRBNFKBP5KDM4EGAA | |
| Caprolactam SCHEMBL16112032 | 0.91 | CRBN (0.70) | OR51E2CRBNFKBP5KDM4EGAA | |
| 2-Pyrrolidone SCHEMBL6929736 | 0.90 | OR51E2 (0.79) | OR51E2CRBNFKBP5KDM4EGAA | |
| 2-Pyrrolidone SCHEMBL14977810 | 0.90 | OR51E2 (0.79) | OR51E2CRBNFKBP5KDM4EGAA | |
| 2-Pyrrolidone SCHEMBL353224 | 0.90 | OR51E2 (0.79) | OR51E2CRBNFKBP5KDM4EGAA | |
| 2-Pyrrolidone SCHEMBL14977562 | 0.90 | OR51E2 (0.79) | OR51E2CRBNFKBP5KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 112 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115754113-A | Method for detecting content of catalyst tetrabutylammonium bromide in piracetam intermediate and finished product through high performance liquid chromatography | 东北制药集团股份有限公司 | 2023-03-07 | — | — | CN | claimed |
| US-10668020-B1 | Pullulan based vinpocetine tablets, lyoplant-tabs, as a buccal solid dosage form | KING ABDULAZIZ UNIVERSITY (SA) | 2020-06-02 | — | — | US | claimed |
| CN-109988092-A | The preparation method for treating the drug Nefiracetam of Alzheimer's disease | 深圳市第二人民医院 | 2019-07-09 | — | — | CN | claimed |
| CN-107493648-A | A kind of sparking electrode for being used to sterilize and preparation method thereof | 中金瑞峰资本管理有限公司 | 2017-12-19 | — | — | CN | claimed |
| CN-104693089-B | Continuous preparation process method of N-acetate pyrrolidone | 沈阳化工大学 | 2017-01-18 | — | — | CN | claimed |
| EP-2850082-B1 | 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido(2,3-d)pyrimidin-6-yl)phenyl)urea as Raf kinase inhibitor for the treatment of cancer | LILLY CO ELI (US) | 2016-05-18 | — | — | EP | claimed |
| CN-102531915-B | Method for preparing ethylene diamine through condensation and ammoniation by using bronsted acid ion liquid to catalyze ethanolamine | HUAIBEI KEDA CHEMICAL CO LTD | 2013-08-07 | — | — | CN | claimed |
| CN-102531915-A | Method for preparing ethylene diamine through condensation and ammoniation by using bronsted acid ion liquid to catalyze ethanolamine | HUAIBEI KEDA CHEMICAL CO LTD | 2012-07-04 | — | — | CN | claimed |
| EP-1063972-A4 | POLYMER BASED RAPIDLY DISSOLVING TABLETS AND PRODUCTION PROCESSES THEREOF | YAMANOUCHI PHARMA TECH INC (US) | 2004-08-04 | — | — | EP | claimed |
| US-6750186-B2 | TABLETS/PELLETS COMPRISING CHELATE AGENT (ETHYLENEDIAMINE TETRAACETIC ACID) FOR SOLUBILIZING MINERAL DEPOSITS (CALCIUM CARBONATE) AND BINDER MATRIX (POLYVINYLPYRROLIDONE); ONLY SLIGHTLY DISSOLVES WITH INTIAL RINSING | BLACK ROBERT (US) | 2004-06-15 | — | — | US | claimed |
| US-20030148907-A1 | Composition and method for cleaning dishwashers | BLACK ROBERT (US) | 2003-08-07 | — | — | US | claimed |
| US-20030129226-A1 | Water soluble polymer-based rapidly dissolving tablets and production processes thereof | YAMANOUCHI PHARMA TECHNOLOGIES, INC. | 2003-07-10 | — | — | US | claimed |
| CN-1094485-C | Process for preparing N-pyrrolidone acetate | NORTHEAST PHARMACEUTICAL GENER (CN) | 2002-11-20 | — | — | CN | claimed |
| US-6465009-B1 | WATER SOLUBLE POLYVINYLPYRROLIDONE, NO SOLVENT, SACCHARIDE OF LOW MOLDABILITY; COMPRESSING, HUMIDIFYING, DRYING | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2002-10-15 | — | — | US | claimed |
| EP-1063972-A1 | POLYMER BASED RAPIDLY DISSOLVING TABLETS AND PRODUCTION PROCESSES THEREOF | Yamanouchi Shaklee Pharma (US) | 2001-01-03 | — | — | EP | claimed |
| WO-1999047126-A1 | POLYMER BASED RAPIDLY DISSOLVING TABLETS AND PRODUCTION PROCESSES THEREOF | YAMANOUCHI SHAKLEE PHARMA (US) | 1999-09-23 | — | — | WO | claimed |
| EP-0089901-B1 | NEW 2-OXO-1-PYRROLIDINEACETIC ACID ESTERS, THEIR METHODS OF PRODUCTION AND THERAPEUTIC COMPOSITIONS CONTAINING THE SAME | PRODES S.A. (ES) | 1987-05-13 | — | — | EP | claimed |
| CN-119075601-A | Organic amine composition, carbon dioxide absorbent and application thereof | 国家能源集团新能源技术研究院有限公司 | 2024-12-06 | — | — | CN | disclosed |
| US-4329286-A | Hydroxyamide acid products and butyrolactone and butyrolactam products | MOBIL OIL CORPORATION (US) | 1982-05-11 | — | — | US | disclosed |
| US-4190588-A | FROM AN ALKENYL SUCCINIC ANHYDRIDE | MOBIL OIL CORPORATION (US) | 1980-02-26 | — | — | US | disclosed |