Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 2-Pyrrolidone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.79 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.67 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Pyrrolidone SCHEMBL14977562 | 1.00 | OR51E2 (0.79) | OR51E2CRBNFKBP5KDM4EGAA | |
| 2-Pyrrolidone SCHEMBL14977810 | 1.00 | OR51E2 (0.79) | OR51E2CRBNFKBP5KDM4EGAA | |
| 2-Pyrrolidone SCHEMBL6929736 | 1.00 | OR51E2 (0.79) | OR51E2CRBNFKBP5KDM4EGAA | |
| 2-Pyrrolidone SCHEMBL22749298 | 0.97 | OR51E2 (0.75) | OR51E2CRBNFKBP5KDM4EGAA | |
| 2-Pyrrolidone SCHEMBL891232 | 0.97 | OR51E2 (0.75) | OR51E2CRBNFKBP5KDM4EGAA | |
| 2-Pyrrolidone SCHEMBL2708992 | 0.97 | OR51E2 (0.75) | OR51E2CRBNFKBP5KDM4EGAA | |
| 2-Pyrrolidone SCHEMBL4655461 | 0.95 | OR51E2 (0.88) | OR51E2CRBNFKBP5KDM4EGAA | |
| 2-Pyrrolidone SCHEMBL3356160 | 0.95 | — | — | |
| Oxalic Acid SCHEMBL28078796 | 0.92 | OR51E2 (0.75) | OR51E2CRBNFKBP5KDM4EGAA | |
| 2-Pyrrolidone SCHEMBL28071444 | 0.92 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2667 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3873418-B1 | ACTIVE INGREDIENT COMPOSITION FOR THE CARE OF HUMAN HAIR | HENKEL AG & CO KGAA (DE) | 2024-07-10 | — | — | EP | claimed |
| EP-4346770-A1 | COMPOSITIONS CONTAINING MEMBRANE-FORMING SUBSTANCES FOR THE PREPARATION OF A PUMPING FOAM | nsc Pharma GmbH & Co. KG (DE) | 2024-04-10 | — | — | EP | claimed |
| WO-2023235226-A1 | SYSTEMS AND METHODS FOR INSECT CONTROL | TERRAMOR, INC. (US) | 2023-12-07 | — | — | WO | claimed |
| EP-4153603-B1 | COMPOSITIONS COMPRISING ORGANO-SILANOL COMPOUNDS, AND APPLICATIONS | EXSYMOL SA (MC) | 2023-11-01 | — | — | EP | claimed |
| EP-3787592-B1 | COMBINATION OF EXTRACTS OF QUINQUINA AND OF LEONTOPODIUM ALPINUM AND OF THE MANGANESE SALT OF L-PYRROLIDONECARBOXYLIC ACID IN THE TREATMENT OF ALOPECIA | FABRE PIERRE DERMO COSMETIQUE (FR) | 2023-08-30 | — | — | EP | claimed |
| CN-116133639-A | Formulations and methods for treating inflammatory diseases | 维奥梅治疗公司 | 2023-05-16 | — | — | CN | claimed |
| US-20230144779-A1 | FORMULATIONS AND METHOD FOR TREATMENT OF INFLAMMATORY DISEASES | VYOME THERAPEUTICS INC. (US) | 2023-05-11 | — | — | US | claimed |
| EP-4129267-A1 | HAIR STYLING EMULSION CONTAINING A NATURAL STYLING POLYMER | Beiersdorf AG (DE) | 2023-02-08 | — | — | EP | claimed |
| EP-3442526-B1 | TOPICAL FORMULATIONS OF BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | MELINTA SUBSIDIARY CORP (US) | 2023-01-04 | — | — | EP | claimed |
| EP-4106713-A1 | SHAVING AID CONTAINING HYDROXYALKYL CELLULOSES | Beiersdorf AG (DE) | 2022-12-28 | — | — | EP | claimed |
| EP-0391124-B1 | Cosmetic composition of double emulsion type | KAO CORP (JP) | 1995-06-21 | — | — | EP | claimed |
| EP-0419148-B1 | Cosmetic composition | SHISEIDO CO LTD (JP) | 1995-03-01 | — | — | EP | claimed |
| EP-0394296-B1 | ASSAY OF A BODY FLUID FOR MEASURING BONE RESORPTION | WASHINGTON RES FOUND (US) | 1995-01-18 | — | — | EP | claimed |
| WO-1994007455-A1 | HAIR TREATMENT AGENT | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1994-04-14 | — | — | WO | claimed |
| EP-0588267-A2 | Method for further processing technical refuse from molasses industry | AMINO GmbH (DE) | 1994-03-23 | — | — | EP | claimed |
| EP-0286901-B1 | WEAKLY ACIDIC BATH AGENTS | Kao Corporation (JP) | 1993-06-23 | — | — | EP | claimed |
| EP-0423015-B1 | EFFERVESCENT NAILS COMPOSITION | L'OREAL (FR) | 1993-05-05 | — | — | EP | claimed |
| EP-0273619-B1 | COSMETIC COMPOSITION | UNILEVER PLC (GB) | 1993-04-07 | — | — | EP | claimed |
| EP-0424282-B1 | SUN TANNING COSMETIC PREPARATION | ERPHAR Société d'Etudes et de Recherches Pharmaceutiques et Cosmétiques (FR) | 1993-03-03 | — | — | EP | claimed |
| EP-0382619-B1 | PROCESS FOR PRODUCING FOAMS FOR COSMETICAL AND PHARMACEUTICAL USE, AND FOAMS OBTAINED BY THIS PROCESS | L'OREAL (FR) | 1992-05-06 | — | — | EP | claimed |