Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 8/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GRM5 | P41594 | 2/20 | 0.38 |
| ▸ | MAT2A | P31153 | 1/20 | 0.37 |
| ▸ | SLC9A5 | Q14940 | 2/20 | 0.36 |
| ▸ | PLAU | P00749 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17768946 | 0.86 | ADORA2A (0.45) | ADORA2AADORA2BADORA3ADORA1GRM5 | |
| SCHEMBL21555705 | 0.85 | ADORA2A (0.44) | ADORA2AADORA2BADORA3ADORA1TDP1 | |
| SCHEMBL20556635 | 0.83 | PDE4A (0.45) | ADORA2AADORA1LMNANPC1ALDH1A1 | |
| SCHEMBL29907694 | 0.81 | TDP1 (0.43) | ADORA2AADORA2BTDP1LMNAGRM5 | |
| SCHEMBL17768977 | 0.81 | TDP1 (0.43) | ADORA2AADORA2BTDP1LMNAGRM5 | |
| SCHEMBL17768969 | 0.81 | TDP1 (0.38) | ADORA2AADORA2BTDP1LMNAGRM5 | |
| SCHEMBL17768707 | 0.79 | ADORA2A (0.49) | ADORA2AADORA2BADORA3ADORA1LMNA | |
| SCHEMBL21555704 | 0.78 | TDP1 (0.38) | ADORA2AADORA2BADORA1TDP1LMNA | |
| SCHEMBL17769045 | 0.77 | CNR2 (0.47) | ADORA2APLAUNPC1ALDH1A1TP53 | |
| SCHEMBL22551815 | 0.76 | ADORA2A (0.36) | ADORA2AADORA2BTDP1LMNAGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10472347-B2 | Aminopyrazine compounds with A2A antagonist properties | MERCK SHARP & DOHME CORP. (US) | 2019-11-12 | — | — | US | disclosed |
| CN-107106558-A | Having a2AAminopyrazine compounds with antagonist properties | 默沙东公司 | 2017-08-29 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10472347-B2 | Aminopyrazine compounds with A2A antagonist properties | ADORA2A, ADORA1, ADORA3 | ADORA2A 1/4885ADORA2B 4/4885ADORA3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.