Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 7/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.43 |
| ▸ | CDK19 | Q9BWU1 | 2/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30701638 | 1.00 | IGF1R (0.51) | IGF1RKMT2AMEN1ALKCDK19 | |
| SCHEMBL15600758 | 0.86 | CCNA2 (0.43) | IGF1RKMT2AALKLRRK2MAPK8 | |
| SCHEMBL29761996 | 0.86 | CCNA2 (0.43) | IGF1RKMT2AALKLRRK2MAPK8 | |
| SCHEMBL30833778 | 0.86 | CCNA2 (0.43) | IGF1RKMT2AALKLRRK2MAPK8 | |
| SCHEMBL22520101 | 0.84 | LRRK2 (0.38) | IGF1RKMT2ALRRK2LCKCDK2 | |
| SCHEMBL23153877 | 0.84 | IGF1R (0.41) | IGF1RKMT2AMEN1ALKCDK19 | |
| SCHEMBL14240127 | 0.84 | IGF1R (0.52) | IGF1RKMT2AMEN1ALKCDK19 | |
| SCHEMBL24179136 | 0.84 | MEN1 (0.44) | IGF1RKMT2AMEN1ALKCDK19 | |
| SCHEMBL25530155 | 0.83 | AURKA (0.47) | IGF1RKMT2AALKMAPK8MAPK9 | |
| SCHEMBL25449173 | 0.83 | MEN1 (0.43) | IGF1RKMT2AMEN1ALKCDK19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116888108-B | Novel EGFR degradation agent | 上海齐鲁制药研究中心有限公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-113896744-B | Selective EGFR inhibitor | 成都先导药物开发股份有限公司 | 2024-04-16 | — | — | CN | disclosed |
| CN-117425646-A | Phosphono derivative, composition thereof and pharmaceutical application thereof | 西藏海思科制药有限公司 | 2024-01-19 | — | — | CN | disclosed |
| CN-116888108-A | Novel EGFR degradation agent | 上海齐鲁制药研究中心有限公司 | 2023-10-13 | — | — | CN | disclosed |
| EP-2844642-B1 | COMPOUNDS FOR INHIBITING CELL PROLIFERATION IN EGFR-DRIVEN CANCERS | ARIAD PHARMA INC (US) | 2019-11-13 | — | — | EP | disclosed |