Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24555863 | 1.00 | NR1H2 (0.47) | NR1H2USP2SMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL14651160 | 1.00 | NR1H2 (0.47) | NR1H2USP2SMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL19385247 | 1.00 | NR1H2 (0.47) | NR1H2USP2SMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL1052491 | 0.92 | NR1H2 (0.50) | NR1H2USP2SMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL2930651 | 0.92 | NR1H2 (0.50) | NR1H2USP2SMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL2930654 | 0.92 | NR1H2 (0.50) | NR1H2USP2SMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL18618383 | 0.91 | NR1H2 (0.44) | NR1H2USP2SMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL10137655 | 0.87 | ALDH1A1 (0.47) | NR1H2USP2SMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL19484302 | 0.87 | ALDH1A1 (0.47) | NR1H2USP2SMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL12723118 | 0.87 | ALDH1A1 (0.47) | NR1H2USP2SMN1; SMN2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3790871-B1 | FURIN INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2024-01-24 | — | — | EP | disclosed |
| WO-2019215341-A1 | FURIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-11-14 | — | — | WO | disclosed |