SCHEMBL21566252

SCHEMBL21566252

Bc1cc2ncc3nc(CCCOCc4ccccc4)n(C)c3c2s1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 1/20 0.38
HRH3 Q9Y5N1 1/20 0.38
CYP1A2 P05177 5/20 0.35
ALDH1A1 P00352 3/20 0.35
TSHR P16473 3/20 0.35
MAOA P21397 2/20 0.35
MAOB P27338 2/20 0.35
CLK4 Q9HAZ1 1/20 0.35
TLR8 Q9NR97 1/20 0.33
TLR7 Q9NYK1 1/20 0.33
RHEB Q15382 1/20 0.33
CYP2C19 P33261 3/20 0.32
CYP2C9 P11712 2/20 0.32
LMNA P02545 1/20 0.32
MAPK1 P28482 1/20 0.32
CYP3A4 P08684 1/20 0.32
L3MBTL1 Q9Y468 2/20 0.32
TDP1 Q9NUW8 1/20 0.32
CYP2D6 P10635 1/20 0.31
MEN1 O00255 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21555633 0.88 HRH4 (0.38) HRH4HRH3CYP1A2ALDH1A1TSHR
SCHEMBL21550537 0.84 PDE4A (0.42) HRH4HRH3CYP1A2ALDH1A1TSHR
SCHEMBL21566204 0.75 MAOA (0.44) HRH4HRH3CYP1A2ALDH1A1TSHR
SCHEMBL21566208 0.72 HRH4 (0.34) HRH4HRH3MAOAMAOBTLR8
SCHEMBL28900436 0.72 TLR7 (0.42) CYP1A2ALDH1A1TSHRTLR7CYP2C19
SCHEMBL30598827 0.72 TLR7 (0.42) CYP1A2ALDH1A1TSHRTLR7CYP2C19
SCHEMBL30598808 0.72 TLR7 (0.36) HRH4HRH3CYP1A2ALDH1A1MAOA
SCHEMBL21557877 0.72 TLR7 (0.36) HRH4HRH3CYP1A2ALDH1A1MAOA
SCHEMBL21550521 0.71 PDE4A (0.41) HRH4CYP1A2ALDH1A1TSHRMAOA
SCHEMBL21550281 0.71 TLR7 (0.46) TLR8TLR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019214546-A1 FUSED RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF 四川科伦博泰生物医药股份有限公司 (CN) 2019-11-14 WO disclosed