Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.52 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | TLR2 | O60603 | 2/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.40 |
| ▸ | CPA1 | P15085 | 1/20 | 0.40 |
| ▸ | CPA2 | P48052 | 1/20 | 0.40 |
| ▸ | CPA4 | Q9UI42 | 1/20 | 0.40 |
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.39 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | GNPAT | O15228 | 1/20 | 0.37 |
| ▸ | GSR | P00390 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13995535 | 1.00 | SIRT6 (0.52) | SIRT6SIRT1CA1CA2TLR2 | |
| SCHEMBL19200235 | 1.00 | SIRT6 (0.52) | SIRT6SIRT1CA1CA2TLR2 | |
| SCHEMBL21566738 | 0.98 | SIRT6 (0.55) | SIRT6SIRT1CA1CA2TLR2 | |
| SCHEMBL22930152 | 0.88 | SIRT6 (0.51) | SIRT6SIRT1CA1CA2TLR2 | |
| SCHEMBL21566849 | 0.85 | SIRT6 (0.52) | SIRT6SIRT1CA1CA2TLR2 | |
| SCHEMBL20196315 | 0.85 | SIRT6 (0.52) | SIRT6SIRT1CA1CA2TLR2 | |
| SCHEMBL14930711 | 0.83 | FOLH1 (0.40) | SIRT6SIRT1FOLH1ITGB3ITGA2B | |
| SCHEMBL19647163 | 0.83 | SIRT6 (0.53) | SIRT6SIRT1CA1CA2TLR2 | |
| SCHEMBL21566739 | 0.83 | SIRT6 (0.53) | SIRT6SIRT1CA1CA2TLR2 | |
| SCHEMBL21566804 | 0.83 | SIRT6 (0.53) | SIRT6SIRT1CA1CA2TLR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190345186-A1 | CALICHEAMICIN DERATIVES AND ANTIBODY DRUG CONJUGATES THEREOF | PFIZER INC. (US) | 2019-11-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190345186-A1 | CALICHEAMICIN DERATIVES AND ANTIBODY DRUG CONJUGATES THEREOF | CALD1, CALU, STT3A | SIRT6 690/4885SIRT1 1329/4885CA1 691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.