Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 8/20 | 0.52 |
| ▸ | RAB9A | P51151 | 8/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.52 |
| ▸ | RELA | Q04206 | 2/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | ACP1 | P24666 | 1/20 | 0.48 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21568159 | 0.89 | DYRK1A (0.58) | DYRK1ANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL21568247 | 0.85 | DYRK1A (0.55) | DYRK1AKMT2AGSK3BMAPTACP1 | |
| SCHEMBL26034949 | 0.84 | DYRK1A (0.61) | DYRK1ANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL21858364 | 0.83 | DYRK1A (0.62) | DYRK1ANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL31206312 | 0.83 | DYRK1A (0.62) | DYRK1ANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL21568347 | 0.82 | DYRK1A (0.58) | DYRK1ANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL23256895 | 0.81 | DYRK1A (0.68) | DYRK1ANPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL26034946 | 0.81 | CXCR2 (0.56) | DYRK1ANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL21568324 | 0.81 | DYRK1A (0.58) | DYRK1ANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL21568098 | 0.81 | DYRK1A (0.46) | DYRK1AALDH1A1KDM4EHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11731985-B2 | Compositions and methods for treating cancer | HB THERAPEUTICS INC. (US) | 2023-08-22 | — | — | US | disclosed |
| WO-2019217509-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER | HB THERAPEUTICS INC. (US) | 2019-11-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11731985-B2 | Compositions and methods for treating cancer | VHL, TP53, NUDT1 | DYRK1A 4664/4885NPC1 424/4885RAB9A 3882/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.