Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 17/20 | 0.58 |
| ▸ | SRC | P12931 | 2/20 | 0.55 |
| ▸ | KDR | P35968 | 2/20 | 0.55 |
| ▸ | STK25 | O00506 | 1/20 | 0.52 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | GAK | O14976 | 1/20 | 0.52 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.52 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.52 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.52 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.52 |
| ▸ | STK17B | O94768 | 1/20 | 0.52 |
| ▸ | STK10 | O94804 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | INSR | P06213 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21569000 | 1.00 | EGFR (0.58) | EGFRERBB2SRCKDRSTK25 | |
| SCHEMBL21569014 | 0.96 | EGFR (0.59) | EGFRERBB2SRCKDRSTK25 | |
| SCHEMBL21569098 | 0.96 | EGFR (0.59) | EGFRERBB2SRCKDRSTK25 | |
| SCHEMBL21569116 | 0.96 | EGFR (0.64) | EGFRERBB2SRCKDRSTK25 | |
| SCHEMBL21569020 | 0.96 | EGFR (0.64) | EGFRERBB2SRCKDRSTK25 | |
| SCHEMBL21569047 | 0.94 | EGFR (0.64) | EGFRERBB2SRCKDRGAK | |
| SCHEMBL21569069 | 0.94 | EGFR (0.64) | EGFRERBB2SRCKDRGAK | |
| SCHEMBL21569002 | 0.93 | EGFR (0.65) | EGFRERBB2SRCKDR | |
| SCHEMBL21569011 | 0.93 | EGFR (0.65) | EGFRERBB2SRCKDR | |
| SCHEMBL21568971 | 0.91 | EGFR (0.67) | EGFRERBB2SRCKDRSTK25 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3222620-B1 | CYANOQUINOLINE DERIVATIVES | TIANJIN HEMAY ONCOLOGY PHARMACEUTICAL CO LTD (CN) | 2019-11-20 | — | — | EP | claimed |