Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.64 |
| ▸ | ERBB2 | P04626 | 17/20 | 0.64 |
| ▸ | SRC | P12931 | 2/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | CIT | O14578 | 1/20 | 0.53 |
| ▸ | GAK | O14976 | 1/20 | 0.53 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.53 |
| ▸ | STK10 | O94804 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | LYN | P07948 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | MET | P08581 | 1/20 | 0.53 |
| ▸ | HCK | P08631 | 1/20 | 0.53 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.53 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.53 |
| ▸ | AXL | P30530 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21569069 | 1.00 | EGFR (0.64) | EGFRERBB2SRCKDRCIT | |
| SCHEMBL21569014 | 0.95 | EGFR (0.59) | EGFRERBB2SRCKDRGAK | |
| SCHEMBL21569098 | 0.95 | EGFR (0.59) | EGFRERBB2SRCKDRGAK | |
| SCHEMBL21569116 | 0.95 | EGFR (0.64) | EGFRERBB2SRCKDRGAK | |
| SCHEMBL21569020 | 0.95 | EGFR (0.64) | EGFRERBB2SRCKDRGAK | |
| SCHEMBL21569000 | 0.94 | EGFR (0.58) | EGFRERBB2SRCKDRGAK | |
| SCHEMBL21568993 | 0.94 | EGFR (0.58) | EGFRERBB2SRCKDRGAK | |
| SCHEMBL21569002 | 0.92 | EGFR (0.65) | EGFRERBB2SRCKDR | |
| SCHEMBL21569011 | 0.92 | EGFR (0.65) | EGFRERBB2SRCKDR | |
| SCHEMBL21569052 | 0.91 | EGFR (0.62) | EGFRERBB2SRCKDRCIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3222620-B1 | CYANOQUINOLINE DERIVATIVES | TIANJIN HEMAY ONCOLOGY PHARMACEUTICAL CO LTD (CN) | 2019-11-20 | — | — | EP | claimed |