Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 20/20 | 0.61 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.61 |
| ▸ | PPARG | P37231 | 1/20 | 0.61 |
| ▸ | PPARD | Q03181 | 1/20 | 0.61 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.61 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.61 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.61 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16639582 | 0.87 | RORC (0.59) | RORCADRA2BPPARGPPARDNR1H3 | |
| SCHEMBL16632944 | 0.86 | RORC (0.59) | RORCADRA2BPPARGPPARDNR1H3 | |
| SCHEMBL16632632 | 0.86 | RORC (0.72) | RORCADRA2BPPARGPPARDNR1H3 | |
| SCHEMBL16633482 | 0.76 | RORC (0.81) | RORCADRA2BPPARGPPARDNR1H3 | |
| Jnj-54119936 SCHEMBL16462313 | 0.76 | RORC (1.00) | RORCADRA2BPPARGPPARDNR1H3 | |
| SCHEMBL21569434 | 0.75 | RORC (0.60) | RORC | |
| SCHEMBL16462458 | 0.74 | RORC (1.00) | RORCADRA2BPPARGPPARDNR1H3 | |
| SCHEMBL16461621 | 0.73 | RORC (1.00) | RORCADRA2BPPARGPPARDNR1H3 | |
| SCHEMBL16632810 | 0.73 | RORC (0.66) | RORCADRA2BPPARGPPARDNR1H3 | |
| SCHEMBL16633249 | 0.72 | RORC (0.68) | RORCADRA2BPPARGPPARDNR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057951-B1 | METHYLENE LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T | JANSSEN PHARMACEUTICA NV (BE) | 2019-11-20 | — | — | EP | disclosed |