Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 2/20 | 0.42 |
| ▸ | P2RY1 | P47900 | 3/20 | 0.41 |
| ▸ | DRD1 | P21728 | 6/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.40 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21572271 | 0.87 | GCK (0.44) | GCKBACE1P2RY1DRD1BACE2 | |
| SCHEMBL18332494 | 0.87 | DRD1 (0.43) | GCKBACE1DRD1PDE10A | |
| SCHEMBL18331711 | 0.77 | AR (0.44) | AXL | |
| SCHEMBL9767048 | 0.75 | P2RY1 (0.54) | P2RY1DRD1KDM4EMEN1CYP1A2 | |
| SCHEMBL29125551 | 0.75 | PDE10A (0.53) | DRD1PDE10AKDM4EMEN1CYP1A2 | |
| SCHEMBL18332109 | 0.73 | AR (0.43) | MEN1KMT2ANPSR1EGFR | |
| SCHEMBL15044336 | 0.71 | MEN1 (0.56) | DRD1PDE10AMEN1KMT2A | |
| SCHEMBL16792626 | 0.71 | MAOB (0.44) | KDM4EMEN1CYP2C19KMT2A | |
| SCHEMBL3706881 | 0.70 | DRD1 (0.43) | DRD1 | |
| SCHEMBL7911670 | 0.69 | MEN1 (0.42) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10479780-B2 | Aminopyrazole derivatives | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2019-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10479780-B2 | Aminopyrazole derivatives | SRC, GRK2, GRK3 | GCK 2426/4885BACE1 4599/4885P2RY1 491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.