Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.35 |
| ▸ | BRAF | P15056 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | GCK | P35557 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18330558 | 0.86 | GCK (0.41) | BRAFKDRGCK | |
| SCHEMBL31221536 | 0.86 | GCK (0.41) | BRAFKDRGCK | |
| Hydrochloric Acid SCHEMBL31221545 | 0.85 | GCK (0.40) | BRAFKDRGCK | |
| SCHEMBL18332225 | 0.81 | MEN1 (0.39) | SLC22A12SCN9ABRAFKDRALOX5AP | |
| SCHEMBL18331937 | 0.81 | ORAI1 (0.39) | SCN9AKDRGCK | |
| SCHEMBL20084620 | 0.81 | GCK (0.35) | GCK | |
| SCHEMBL20084741 | 0.79 | GCK (0.34) | GCK | |
| SCHEMBL20084126 | 0.78 | KEAP1 (0.42) | SCN9ABRAFKDRALOX5APFEN1 | |
| SCHEMBL18330595 | 0.78 | MEN1 (0.52) | BRAFALOX5APFEN1GCK | |
| SCHEMBL18331943 | 0.77 | MEN1 (0.43) | SLC22A12SCN9ABRAFALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10479780-B2 | Aminopyrazole derivatives | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2019-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10479780-B2 | Aminopyrazole derivatives | SRC, GRK2, GRK3 | SLC22A12 3775/4885SCN9A 3831/4885BRAF 462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.