Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 19/20 | 0.80 |
| ▸ | PLA2G1B | P04054 | 6/20 | 0.76 |
| ▸ | PLA2G10 | O15496 | 6/20 | 0.76 |
| ▸ | PLA2G2E | Q9NZK7 | 6/20 | 0.76 |
| ▸ | PLA2G5 | P39877 | 5/20 | 0.76 |
| ▸ | PLA2G2F | Q9BZM2 | 4/20 | 0.76 |
| ▸ | PLA2G2D | Q9UNK4 | 4/20 | 0.76 |
| ▸ | PLA2G6 | O60733 | 1/20 | 0.76 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.76 |
| ▸ | PLA2G12B | Q9BX93 | 1/20 | 0.76 |
| ▸ | PLA2G12A | Q9BZM1 | 1/20 | 0.76 |
| ▸ | PLA2G3 | Q9NZ20 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7112890 | 0.99 | PLA2G2A (0.79) | PLA2G2APLA2G1BPLA2G10PLA2G2EPLA2G5 | |
| SCHEMBL2157074 | 0.91 | PLA2G2A (0.77) | PLA2G2APLA2G1BPLA2G10PLA2G2EPLA2G5 | |
| SCHEMBL7976593 | 0.91 | PLA2G2A (0.66) | PLA2G2APLA2G1BPLA2G10PLA2G2EPLA2G5 | |
| SCHEMBL5319862 | 0.90 | PLA2G2A (0.77) | PLA2G2APLA2G1BPLA2G10PLA2G2EPLA2G5 | |
| SCHEMBL7962736 | 0.89 | PLA2G2A (1.00) | PLA2G2APLA2G1BPLA2G10PLA2G2EPLA2G5 | |
| SCHEMBL2157506 | 0.87 | PLA2G2A (0.80) | PLA2G2APLA2G1BPLA2G10PLA2G2EPLA2G5 | |
| SCHEMBL7837809 | 0.87 | PLA2G2A (0.77) | PLA2G2APLA2G1BPLA2G10PLA2G2EPLA2G5 | |
| Varespladib SCHEMBL29358982 | 0.86 | PLA2G2A (1.00) | PLA2G2APLA2G1BPLA2G10PLA2G2EPLA2G5 | |
| Varespladib SCHEMBL26726 | 0.86 | PLA2G2A (1.00) | PLA2G2APLA2G1BPLA2G10PLA2G2EPLA2G5 | |
| SCHEMBL12023837 | 0.85 | PLA2G2A (0.78) | PLA2G2APLA2G1BPLA2G10PLA2G2EPLA2G5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1157704-A1 | REMEDIES OR PREVENTIVES FOR ISCHEMIC REFLOW FAILURE | SHIONOGI & CO., LTD. (JP) | 2001-11-28 | — | — | EP | claimed |
| EP-1007056-A1 | METHOD FOR THE TREATMENT OF CYSTIC FIBROSIS | ELI LILLY AND COMPANY (US) | 2000-06-14 | — | — | EP | claimed |
| WO-1999016453-A1 | METHOD FOR THE TREATMENT OF CYSTIC FIBROSIS | ELI LILLY AND COMPANY (US) | 1999-04-08 | — | — | WO | claimed |
| CN-116585306-A | PLA2 inhibitors for immediate treatment of hymenoptera toxicity and other conditions due to histamine release | 奥菲瑞克斯股份有限公司 | 2023-08-15 | — | — | CN | disclosed |
| CN-109562098-B | PLA2 inhibitors for immediate treatment of hymenoptera toxicity and other conditions due to histamine release | 奥菲瑞克斯股份有限公司 | 2023-04-21 | — | — | CN | disclosed |
| EP-2341045-A1 | [[3-(2-amino-1,2-dioxoethyl)-2-ethyl-1-(phenylmethyl)-11H-indol-4-yl]oxy]acetic acid (acyloxy)alkyl or ((alkoxycarbonyl)oxy)alkyl ester as SPLA2 inhibitor | Eli Lilly and Company (US) | 2011-07-06 | — | — | EP | disclosed |
| WO-2007110230-A2 | SECRETED PROTEINS AS EARLY MARKERS AND DRUG TARGETS FOR AUTOIMMUNITY, TUMORIGENESIS AND INFECTIONS | INSTITUT PASTEUR (FR) | 2007-10-04 | — | — | WO | disclosed |
| EP-1840573-A1 | Secreted proteins as early markers and drug targets for autoimmunity, tumorigenesis and infections | INSTITUT PASTEUR (FR) | 2007-10-03 | — | — | EP | disclosed |
| EP-1073440-B1 | sPLA 2 INHIBITOR ESTERS | LILLY CO ELI (US) | 2004-10-20 | — | — | EP | disclosed |
| EP-1181276-A1 | MORPHOLINO-N-ETHYL ESTER DERIVATIVE OF AN INDOLE SPLA-2 INHIBITOR | ELI LILLY AND COMPANY (US) | 2002-02-27 | — | — | EP | disclosed |
| CN-1299277-A | Pharmaceutical composition containing phospholipase inhibitor sodium [ 3- (2-amino-1, 2-dioxyethyl) -2-ethyl-1 (benzyl) -1H-indol-4-yl ] oxy ] acetate | SHIONOGI & CO (JP) | 2001-06-13 | — | — | CN | disclosed |
| EP-1007046-A4 | METHOD FOR TREATMENT OF CHRONIC BRONCHITIS | LILLY CO ELI (US) | 2000-11-29 | — | — | EP | disclosed |
| WO-2000069818-A1 | MORPHOLINO-N-ETHYL ESTER DERIVATIVE OF AN INDOLE sPLA2 INHIBITOR | ELI LILLY AND COMPANY (US) | 2000-11-23 | — | — | WO | disclosed |
| EP-1007046-A1 | 1H-INDOLE-3-GLYOXYLAMIDES FOR THE TREATMENT OF CHRONIC BRONCHITIS | ELI LILLY AND COMPANY (US) | 2000-06-14 | — | — | EP | disclosed |
| US-5919943-A | INHIBITION OF SPLA2 | ELI LILLY AND COMPANY (US) | 1999-07-06 | — | — | US | disclosed |
| US-5919810-A | SEPTIC SHOCK | ELI LILLY AND COMPANY (US) | 1999-07-06 | — | — | US | disclosed |
| WO-1998042343-A1 | METHOD FOR TREATMENT OF CHRONIC BRONCHITIS | ELI LILLY AND COMPANY (US) | 1998-10-01 | — | — | WO | disclosed |
| US-5733923-A | SECRETORY PANCREATIC PHOSPHOLIPASE A2 | ELI LILLY AND COMPANY (US) | 1998-03-31 | — | — | US | disclosed |