Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 8/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | MRGPRX1 | Q96LB2 | 2/20 | 0.31 |
| ▸ | OXTR | P30559 | 1/20 | 0.31 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 2/20 | 0.31 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.30 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | ABAT | P80404 | 1/20 | 0.30 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.30 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | RXRB | P28702 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21572612 | 0.86 | MEN1 (0.51) | MEN1KMT2AKEAP1MRGPRX1SMN1; SMN2 | |
| SCHEMBL20084783 | 0.81 | GCK (0.46) | GCKMEN1KMT2ADHODHADRB3 | |
| SCHEMBL18331768 | 0.80 | MEN1 (0.42) | GCKMEN1KMT2AKEAP1DHODH | |
| SCHEMBL18330558 | 0.79 | GCK (0.41) | GCKMEN1KMT2AKEAP1ORAI1 | |
| SCHEMBL31221536 | 0.79 | GCK (0.41) | GCKMEN1KMT2AKEAP1ORAI1 | |
| Hydrochloric Acid SCHEMBL31221545 | 0.78 | GCK (0.40) | GCKMEN1KMT2AKEAP1ORAI1 | |
| SCHEMBL18332197 | 0.77 | GCK (0.45) | GCKMEN1KMT2ADHODHADRB3 | |
| SCHEMBL20084464 | 0.75 | GCK (0.43) | GCKMEN1KMT2AORAI1SMN1; SMN2 | |
| SCHEMBL21971949 | 0.75 | GCK (0.38) | GCKMEN1KMT2ADHODHADRB3 | |
| SCHEMBL20084192 | 0.75 | GCK (0.39) | GCKRXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10479780-B2 | Aminopyrazole derivatives | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2019-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10479780-B2 | Aminopyrazole derivatives | SRC, GRK2, GRK3 | GCK 2426/4885MEN1 3006/4885KMT2A 1100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.