Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 16/20 | 0.83 |
| ▸ | FLT3 | P36888 | 4/20 | 0.83 |
| ▸ | KDR | P35968 | 3/20 | 0.83 |
| ▸ | AXL | P30530 | 2/20 | 0.83 |
| ▸ | PLK4 | O00444 | 1/20 | 0.83 |
| ▸ | STK25 | O00506 | 1/20 | 0.83 |
| ▸ | CIT | O14578 | 1/20 | 0.83 |
| ▸ | AURKA | O14965 | 1/20 | 0.83 |
| ▸ | CHUK | O15111 | 1/20 | 0.83 |
| ▸ | MUSK | O15146 | 1/20 | 0.83 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.83 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.83 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.83 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.83 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.83 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.83 |
| ▸ | JAK2 | O60674 | 1/20 | 0.83 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.83 |
| ▸ | PAK3 | O75914 | 1/20 | 0.83 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20216833 | 1.00 | MET (0.83) | METFLT3KDRAXLPLK4 | |
| SCHEMBL20080901 | 0.97 | MET (0.79) | METFLT3KDRAXLPLK4 | |
| SCHEMBL16069963 | 0.92 | MET (0.89) | METFLT3KDRAXLPLK4 | |
| SCHEMBL16069974 | 0.91 | MET (0.88) | METFLT3KDRAXLPLK4 | |
| SCHEMBL16070096 | 0.91 | MET (0.88) | METFLT3KDRAXLPLK4 | |
| Foretinib SCHEMBL30498609 | 0.91 | MET (1.00) | METFLT3KDRAXLPLK4 | |
| SCHEMBL29693444 | 0.91 | MET (1.00) | METFLT3KDRAXLPLK4 | |
| Foretinib SCHEMBL371804 | 0.91 | MET (1.00) | METFLT3KDRAXLPLK4 | |
| Foretinib SCHEMBL29358674 | 0.91 | MET (1.00) | METFLT3KDRAXLPLK4 | |
| SCHEMBL372153 | 0.91 | MET (1.00) | METFLT3KDRAXLPLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768796-B1 | PROCESS FOR PREPARING QUINOLINE DERIVATIVES | EXELIXIS INC (US) | 2019-11-20 | — | — | EP | disclosed |