Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.70 |
| ▸ | ERBB2 | P04626 | 18/20 | 0.70 |
| ▸ | STK25 | O00506 | 2/20 | 0.60 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.60 |
| ▸ | GAK | O14976 | 2/20 | 0.60 |
| ▸ | STK17B | O94768 | 2/20 | 0.60 |
| ▸ | STK10 | O94804 | 2/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.60 |
| ▸ | ABL1 | P00519 | 2/20 | 0.60 |
| ▸ | LCK | P06239 | 2/20 | 0.60 |
| ▸ | FYN | P06241 | 2/20 | 0.60 |
| ▸ | FES | P07332 | 2/20 | 0.60 |
| ▸ | CSF1R | P07333 | 2/20 | 0.60 |
| ▸ | YES1 | P07947 | 2/20 | 0.60 |
| ▸ | LYN | P07948 | 2/20 | 0.60 |
| ▸ | MET | P08581 | 2/20 | 0.60 |
| ▸ | HCK | P08631 | 2/20 | 0.60 |
| ▸ | FGR | P09769 | 2/20 | 0.60 |
| ▸ | WEE2 | P0C1S8 | 2/20 | 0.60 |
| ▸ | SRC | P12931 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19389774 | 0.90 | EGFR (0.69) | EGFRERBB2STK25CHEK1GAK | |
| SCHEMBL19389777 | 0.89 | EGFR (0.69) | EGFRERBB2 | |
| SCHEMBL18933463 | 0.84 | EGFR (0.67) | EGFRERBB2STK25CHEK1GAK | |
| SCHEMBL14864912 | 0.84 | EGFR (0.66) | EGFRERBB2STK25CHEK1GAK | |
| SCHEMBL14864919 | 0.83 | EGFR (0.66) | EGFRERBB2ERBB4ERBB3 | |
| SCHEMBL18933466 | 0.81 | EGFR (0.71) | EGFRERBB2STK25CHEK1GAK | |
| SCHEMBL2026232 | 0.80 | EGFR (0.82) | EGFRERBB2STK25CHEK1GAK | |
| SCHEMBL14925319 | 0.79 | EGFR (1.00) | EGFRERBB2STK25CHEK1GAK | |
| SCHEMBL4964726 | 0.79 | EGFR (0.84) | EGFRERBB2 | |
| SCHEMBL5989738 | 0.79 | EGFR (0.84) | EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3222620-B1 | CYANOQUINOLINE DERIVATIVES | TIANJIN HEMAY ONCOLOGY PHARMACEUTICAL CO LTD (CN) | 2019-11-20 | — | — | EP | disclosed |