Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 19/20 | 0.52 |
| ▸ | IDH2 | P48735 | 5/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21573480 | 1.00 | IDH1 (0.52) | IDH1IDH2 | |
| SCHEMBL16370163 | 0.91 | IDH1 (0.57) | IDH1IDH2 | |
| SCHEMBL17971624 | 0.88 | IDH1 (0.58) | IDH1IDH2 | |
| SCHEMBL21573412 | 0.83 | IDH1 (0.67) | IDH1IDH2 | |
| SCHEMBL21573402 | 0.83 | IDH1 (0.51) | IDH1IDH2 | |
| SCHEMBL16393080 | 0.80 | IDH1 (0.57) | IDH1IDH2 | |
| SCHEMBL18557120 | 0.79 | IDH1 (0.53) | IDH1IDH2 | |
| SCHEMBL21573411 | 0.78 | IDH1 (0.50) | IDH1IDH2 | |
| SCHEMBL16392810 | 0.76 | IDH1 (0.67) | IDH1IDH2 | |
| SCHEMBL21573226 | 0.75 | IDH1 (0.84) | IDH1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3019483-B1 | THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE | AGIOS PHARMACEUTICALS INC (US) | 2019-11-20 | — | — | EP | disclosed |