Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 18/20 | 0.65 |
| ▸ | IDH2 | P48735 | 7/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16393283 | 0.90 | IDH1 (0.79) | IDH1IDH2 | |
| SCHEMBL16393075 | 0.90 | IDH1 (0.79) | IDH1IDH2 | |
| SCHEMBL21573412 | 0.89 | IDH1 (0.67) | IDH1IDH2 | |
| SCHEMBL18557108 | 0.87 | IDH1 (0.87) | IDH1IDH2 | |
| SCHEMBL17971618 | 0.87 | IDH1 (0.87) | IDH1IDH2 | |
| SCHEMBL21573251 | 0.86 | IDH1 (0.81) | IDH1IDH2 | |
| SCHEMBL21573248 | 0.85 | IDH1 (0.58) | IDH1IDH2 | |
| SCHEMBL29975808 | 0.81 | IDH1 (0.89) | IDH1IDH2 | |
| SCHEMBL21573307 | 0.81 | IDH1 (0.89) | IDH1IDH2 | |
| SCHEMBL16392938 | 0.81 | IDH1 (0.89) | IDH1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3686190-A1 | SYNTHESIS OF THERAPEUTICALLY ACTIVE COMPOUNDS | Agios Pharmaceuticals, Inc. (US) | 2020-07-29 | — | — | EP | disclosed |
| EP-3019483-B1 | THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE | AGIOS PHARMACEUTICALS INC (US) | 2019-11-20 | — | — | EP | disclosed |