Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 15/20 | 0.60 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.60 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.38 |
| ▸ | CDK2 | P24941 | 4/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21573654 | 0.88 | ROCK2 (0.60) | ROCK2ROCK1CCNE1CDK2 | |
| SCHEMBL21573606 | 0.86 | ROCK2 (0.65) | ROCK2ROCK1CCNE1CDK2 | |
| SCHEMBL21573609 | 0.86 | ROCK2 (0.62) | ROCK2ROCK1 | |
| SCHEMBL21573569 | 0.80 | ROCK2 (0.64) | ROCK2ROCK1CCNE1CDK2 | |
| SCHEMBL21573527 | 0.79 | ROCK2 (0.64) | ROCK2ROCK1CCNE1CDK2 | |
| SCHEMBL21573645 | 0.78 | ROCK2 (0.62) | ROCK2ROCK1 | |
| SCHEMBL16638092 | 0.75 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL24741296 | 0.73 | CYP1A2 (0.53) | CCNE1CDK2 | |
| SCHEMBL20783917 | 0.72 | ROCK2 (0.63) | ROCK2ROCK1 | |
| SCHEMBL21573537 | 0.72 | ROCK2 (0.35) | ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3055301-B1 | (2-(5-ISOINDOLIN-2-YL)PYRIMIDIN-4-YL)-AMINE DERIVATIVES AS RHO KINASE INHIBITORS FOR TREATING AUTOIMMUNE DISEASES | KADMON CORP LLC (US) | 2019-11-20 | — | — | EP | disclosed |