Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.50 |
| ▸ | EBP | Q15125 | 2/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | EBPL | Q9BY08 | 1/20 | 0.47 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD5 | P21918 | 1/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2157438 | 0.93 | DRD3 (0.46) | SIGMAR1EBPTMEM97DRD3MEN1 | |
| SCHEMBL2158498 | 0.89 | SIGMAR1 (0.58) | SIGMAR1DRD3DRD2KDM4ECACNA1F | |
| SCHEMBL7032807 | 0.88 | DRD3 (0.53) | DRD3DRD2KMT2ACACNA1FDRD1 | |
| Hydrochloric Acid SCHEMBL2158183 | 0.87 | DRD3 (0.52) | DRD3DRD2CACNA1FDRD1DRD4 | |
| SCHEMBL1332065 | 0.85 | SIGMAR1 (0.61) | SIGMAR1EBPTMEM97ADRA1DADRA1A | |
| SCHEMBL2158301 | 0.85 | KMT2A (0.57) | SIGMAR1DRD3DRD2MEN1KMT2A | |
| SCHEMBL2157909 | 0.84 | KDM4E (0.47) | SIGMAR1DRD3MEN1KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL2157282 | 0.84 | KMT2A (0.56) | DRD3DRD2MEN1KMT2AKDM4E | |
| SCHEMBL2157673 | 0.83 | DRD3 (0.51) | SIGMAR1DRD3DRD2CACNA1FDRD1 | |
| SCHEMBL2157502 | 0.81 | DRD3 (0.51) | SIGMAR1DRD3DRD2KDM4ECACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183374-B2 | Piperidine and piperazine derivatives | M'S SCIENCE CORPORATION (JP) | 2012-05-22 | — | — | US | disclosed |
| EP-2340835-A1 | Piperidine and piperazine derivatives | M's Science Corporation (JP) | 2011-07-06 | — | — | EP | disclosed |
| EP-1976525-B1 | PIPERIDINE AND PIPERAZINE DERIVATIVES | MS SCIENCE CORP (JP) | 2010-11-03 | — | — | EP | disclosed |