Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.53 |
| ▸ | JAK2 | O60674 | 3/20 | 0.53 |
| ▸ | JAK3 | P52333 | 3/20 | 0.53 |
| ▸ | AURKA | O14965 | 2/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.53 |
| ▸ | PAK4 | O96013 | 2/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.53 |
| ▸ | CSF1R | P07333 | 2/20 | 0.53 |
| ▸ | RET | P07949 | 2/20 | 0.53 |
| ▸ | IGF1R | P08069 | 2/20 | 0.53 |
| ▸ | MET | P08581 | 2/20 | 0.53 |
| ▸ | PIM1 | P11309 | 2/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.53 |
| ▸ | PRKACA | P17612 | 2/20 | 0.53 |
| ▸ | FLT1 | P17948 | 2/20 | 0.53 |
| ▸ | LTK | P29376 | 2/20 | 0.53 |
| ▸ | GRK5 | P34947 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20712720 | 0.87 | TYRO3 (0.52) | BTKJAK2JAK3AURKADAPK3 | |
| SCHEMBL20449815 | 0.82 | AAK1 (0.75) | GSK3AAAK1 | |
| SCHEMBL20699102 | 0.82 | AAK1 (0.75) | GSK3AAAK1 | |
| SCHEMBL20449816 | 0.82 | AAK1 (0.54) | BTKJAK2JAK3AURKADAPK3 | |
| SCHEMBL21575375 | 0.82 | JAK2 (0.53) | BTKJAK2JAK3AURKADAPK3 | |
| SCHEMBL18197623 | 0.80 | BTK (0.61) | BTKJAK2JAK3AURKADAPK3 | |
| SCHEMBL21575358 | 0.79 | TBK1 (0.63) | BTKJAK2JAK3AURKADAPK3 | |
| SCHEMBL20699252 | 0.79 | AAK1 (0.62) | BTKAAK1 | |
| SCHEMBL20752338 | 0.78 | BTK (0.52) | BTKJAK2JAK3AURKADAPK3 | |
| SCHEMBL28626835 | 0.77 | AAK1 (0.56) | BTKAAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3356330-B1 | BIARYL KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2019-11-20 | — | — | EP | disclosed |