Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.47 |
| ▸ | CTSS | P25774 | 2/20 | 0.46 |
| ▸ | CTSK | P43235 | 2/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | RIOK2 | Q9BVS4 | 4/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | GSK3A | P49840 | 2/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.43 |
| ▸ | GCK | P35557 | 1/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31089887 | 1.00 | SCN9A (0.47) | SCN9ACTSSCTSKCTSBRIOK2 | |
| SCHEMBL31089725 | 0.85 | SCN9A (0.51) | SCN9ACTSSCTSKCTSBHDAC4 | |
| SCHEMBL31089761 | 0.84 | SCN9A (0.42) | SCN9ACTSSCTSKRIOK2GCK | |
| SCHEMBL21581584 | 0.84 | SCN9A (0.42) | SCN9ACTSSCTSKRIOK2GCK | |
| SCHEMBL31089806 | 0.84 | SCN9A (0.45) | SCN9ACTSSCTSKCTSBRIOK2 | |
| SCHEMBL21581665 | 0.80 | RIOK2 (0.51) | RIOK2GSK3AMAPK10GCKP2RX3 | |
| SCHEMBL21580634 | 0.79 | RIOK2 (0.50) | RIOK2GSK3AMAPK10GCKLNPEP | |
| SCHEMBL21580636 | 0.79 | RIOK2 (0.50) | RIOK2GSK3AMAPK10GCKLNPEP | |
| SCHEMBL21611234 | 0.75 | SCN9A (0.42) | SCN9ACTSSCTSKHDAC4HDAC1 | |
| SCHEMBL29774910 | 0.74 | SCN9A (0.52) | SCN9ACTSSCTSKCTSBHDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019222816-A1 | SUBSTITUTED-PYRIDINYL COMPOUNDS AND USES THEREOF | BIONOMICS LIMITED (AU) | 2019-11-28 | — | — | WO | disclosed |