Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25188346 | 0.82 | HTT (0.43) | MAPTHTTALDH1A1KDM4ENPC1 | |
| SCHEMBL21581991 | 0.80 | ALDH1A1 (0.39) | MAPTALDH1A1PKMKDM4ELMNA | |
| SCHEMBL21590387 | 0.78 | CYP1A2 (0.36) | HTTALDH1A1PKMKDM4ENPC1 | |
| SCHEMBL28031712 | 0.75 | HTT (0.43) | MAPTHTTALDH1A1KDM4ECYP1A2 | |
| SCHEMBL29381080 | 0.75 | NPSR1 (0.50) | MAPTHTTALDH1A1KDM4EGAA | |
| SCHEMBL24227932 | 0.75 | NPSR1 (0.50) | MAPTHTTALDH1A1KDM4EGAA | |
| SCHEMBL5162218 | 0.74 | CYP1A2 (0.34) | HTTALDH1A1CYP1A2GAAKMT2A | |
| SCHEMBL30375828 | 0.74 | HTT (0.59) | MAPTHTTALDH1A1KDM4ECYP1A2 | |
| SCHEMBL29383530 | 0.74 | HTT (0.35) | MAPTHTTALDH1A1KDM4ENPC1 | |
| SCHEMBL1425084 | 0.74 | HTT (0.35) | MAPTHTTALDH1A1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3728257-A1 | AUTOTAXIN INHIBITORS AND USES THEREOF | Fronthera U.S. Pharmaceuticals LLC (US) | 2020-10-28 | — | — | EP | disclosed |
| WO-2019228403-A1 | AUTOTAXIN INHIBITORS AND USES THEREOF | FRONTHERA U.S. PHARMACEUTICALS LLC (US) | 2019-12-05 | — | — | WO | disclosed |