Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 17/20 | 0.61 |
| ▸ | ERG | P11308 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2158262 | 0.92 | SMO (0.59) | SMOERG | |
| SCHEMBL2158490 | 0.90 | SMO (0.52) | SMOERG | |
| SCHEMBL14716247 | 0.79 | SMN1; SMN2 (0.42) | SMOFAAH | |
| SCHEMBL1459244 | 0.78 | SMO (0.46) | SMO | |
| Trifluoroacetic Acid SCHEMBL2158204 | 0.77 | SMO (0.90) | SMOERG | |
| SCHEMBL14716443 | 0.75 | SMN1; SMN2 (0.42) | SMOFAAH | |
| Trifluoroacetic Acid SCHEMBL2158485 | 0.70 | SMO (0.71) | SMOERG | |
| Trifluoroacetic Acid SCHEMBL2158258 | 0.69 | SMO (0.88) | SMOERG | |
| Trifluoroacetic Acid SCHEMBL2158300 | 0.68 | SMO (0.74) | SMOERG | |
| Trifluoroacetic Acid SCHEMBL2158347 | 0.68 | SMO (0.74) | SMOERG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110183974-A1 | 1,2,4-OXADIAZOLE SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS | INSTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI (IT) | 2011-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110183974-A1 | 1,2,4-OXADIAZOLE SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS | SHH, SMO, GLI1 | SMO 2/4885ERG 2205/4885FAAH 4313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.