Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 12/20 | 0.41 |
| ▸ | SMO | Q99835 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2158262 | 0.86 | SMO (0.59) | SMN1; SMN2SMO | |
| SCHEMBL14716443 | 0.86 | SMN1; SMN2 (0.42) | SMN1; SMN2FAAHSMORAB9A | |
| SCHEMBL1459244 | 0.81 | SMO (0.46) | SMN1; SMN2SMORAB9A | |
| SCHEMBL1460137 | 0.79 | CNR2 (0.41) | FAAHNPC1RAB9A | |
| SCHEMBL2158209 | 0.79 | SMO (0.61) | FAAHSMO | |
| Trifluoroacetic Acid SCHEMBL14716245 | 0.77 | SMO (0.61) | SMN1; SMN2FAAHSMONPC1RAB9A | |
| SCHEMBL14716258 | 0.67 | SMO (0.69) | FAAHSMONPC1RAB9A | |
| SCHEMBL3769466 | 0.67 | FAAH (0.61) | FAAHNPC1RAB9A | |
| Trifluoroacetic Acid SCHEMBL14716442 | 0.66 | SMO (0.57) | SMN1; SMN2SMO | |
| SCHEMBL2159047 | 0.65 | SMO (0.55) | SMN1; SMN2SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130053396-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS | INSTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.R.L. (IT) | 2013-02-28 | — | — | US | claimed |
| US-20130053396-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS | INSTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.R.L. (IT) | 2013-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130053396-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS | SHH, SMO, GLI1 | SMN1; SMN2 1155/4885FAAH 4026/4885SMO 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.