Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 20/20 | 0.74 |
| ▸ | MMP2 | P08253 | 8/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17871087 | 0.85 | ADAMTS5 (1.00) | ADAMTS5MMP2 | |
| SCHEMBL20708420 | 0.73 | ADAMTS5 (0.79) | ADAMTS5MMP2 | |
| SCHEMBL17871483 | 0.72 | ADAMTS5 (1.00) | ADAMTS5MMP2 | |
| SCHEMBL17871140 | 0.72 | ADAMTS5 (1.00) | ADAMTS5MMP2 | |
| SCHEMBL17871357 | 0.71 | ADAMTS5 (1.00) | ADAMTS5MMP2 | |
| SCHEMBL17871085 | 0.71 | ADAMTS5 (1.00) | ADAMTS5MMP2 | |
| SCHEMBL17871336 | 0.71 | ADAMTS5 (1.00) | ADAMTS5MMP2 | |
| SCHEMBL17871544 | 0.70 | ADAMTS5 (1.00) | ADAMTS5MMP2 | |
| SCHEMBL17871259 | 0.70 | ADAMTS5 (1.00) | ADAMTS5MMP2 | |
| SCHEMBL17871150 | 0.70 | ADAMTS5 (1.00) | ADAMTS5MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3575294-A1 | 5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | Les Laboratoires Servier (FR) | 2019-12-04 | — | — | EP | disclosed |