Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 18/20 | 0.81 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14984949 | 1.00 | METAP2 (0.81) | METAP2ABCB11LMNAMEN1ALDH1A1 | |
| SCHEMBL23710407 | 1.00 | METAP2 (0.81) | METAP2ABCB11LMNAMEN1ALDH1A1 | |
| SCHEMBL6883791 | 1.00 | METAP2 (0.81) | METAP2ABCB11LMNAMEN1ALDH1A1 | |
| SCHEMBL18458206 | 1.00 | METAP2 (0.81) | METAP2ABCB11LMNAMEN1ALDH1A1 | |
| SCHEMBL6883789 | 1.00 | METAP2 (0.81) | METAP2ABCB11LMNAMEN1ALDH1A1 | |
| SCHEMBL13799962 | 0.94 | METAP2 (0.78) | METAP2ABCB11LMNAMEN1ALDH1A1 | |
| SCHEMBL19880170 | 0.94 | METAP2 (0.82) | METAP2ABCB11LMNAMEN1ALDH1A1 | |
| SCHEMBL18458208 | 0.94 | METAP2 (0.82) | METAP2ABCB11LMNAMEN1ALDH1A1 | |
| SCHEMBL21017027 | 0.93 | METAP2 (0.76) | METAP2ABCB11LMNAMEN1ALDH1A1 | |
| SCHEMBL21880698 | 0.93 | METAP2 (0.76) | METAP2ABCB11LMNAMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3574922-A1 | MODIFIED OR POLYMER-CONJUGATED FUMAGILLOL METAP2 INHIBITORS FOR USE IN IMPROVING OR RESTORING INSULIN SENSITIVITY | Syndevrx, Inc. (US) | 2019-12-04 | — | — | EP | disclosed |