Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.43 |
| ▸ | JAK3 | P52333 | 12/20 | 0.43 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3707696 | 0.80 | PIK3CG (0.49) | JAK2JAK3SMPD3PIK3CGFLT3 | |
| SCHEMBL21585146 | 0.71 | PIK3CG (0.44) | JAK2JAK3SMPD3PIK3CGPIK3CD | |
| SCHEMBL15308491 | 0.71 | PIK3CG (0.49) | JAK2JAK3SMPD3PIK3CG | |
| SCHEMBL17657815 | 0.71 | PIK3CG (0.49) | JAK2JAK3PIK3CGPIK3CDPIK3CA | |
| SCHEMBL5741027 | 0.70 | SMPD3 (0.50) | JAK2JAK3SMPD3PIK3CG | |
| SCHEMBL22161943 | 0.70 | SMPD3 (0.47) | SMPD3 | |
| SCHEMBL24880503 | 0.70 | JAK2 (0.41) | JAK2JAK3SMPD3PIK3CG | |
| SCHEMBL21555751 | 0.70 | JAK2 (0.41) | JAK2JAK3SMPD3PIK3CG | |
| SCHEMBL21555747 | 0.69 | HTR6 (0.49) | JAK2JAK3SMPD3PIK3CGHTR6 | |
| SCHEMBL21555749 | 0.68 | JAK2 (0.40) | JAK2JAK3SMPD3PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019228404-A1 | NOVEL PHOSPHOINOSITIDE 3-KINASE INHIBITOR AND PREPARATION METHOD AND USE THEREOF | 信达生物制药(苏州)有限公司 (CN) | 2019-12-05 | — | — | WO | disclosed |