Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 8/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | NMT1 | P30419 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL213660 | 0.94 | TOP2A (0.35) | TOP2AHSP90AB1MKNK1RAB9AMEN1 | |
| SCHEMBL216161 | 0.92 | NEK2 (0.33) | HSP90AB1RAB9AMEN1NPC1KMT2A | |
| SCHEMBL214823 | 0.86 | CHEK2 (0.35) | TOP2AHSP90AB1RAB9AMEN1NPC1 | |
| Hydrochloric Acid SCHEMBL213800 | 0.85 | CHEK2 (0.35) | TOP2AHSP90AB1RAB9AMEN1NPC1 | |
| SCHEMBL214620 | 0.80 | CHEK2 (0.39) | RAB9AMEN1NPC1KMT2ASLC6A4 | |
| Hydrochloric Acid SCHEMBL216277 | 0.79 | CHEK2 (0.39) | RAB9AMEN1NPC1KMT2ASLC6A4 | |
| SCHEMBL214751 | 0.79 | BTK (0.38) | RAB9AMEN1NPC1KMT2AKDM4E | |
| SCHEMBL216764 | 0.77 | KCNH2 (0.40) | RAB9AKDM4ELMNAMAPT | |
| SCHEMBL214506 | 0.77 | MAPK14 (0.34) | RAB9AMEN1NPC1KMT2AKDM4E | |
| SCHEMBL214517 | 0.77 | RAB9A (0.37) | RAB9AMEN1NPC1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088767-B2 | JAK-2 modulators and methods of use | EXELIXIS, INC. (US) | 2012-01-03 | — | — | US | disclosed |
| EP-2061768-A2 | IMIDAZOLE-4,5-DICARBOXAMIDE DERIVATIVES AS JAK-2 MODULATORS | Exelixis, Inc. (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008042282-A2 | IMIDAZOLE-4, 5-DICARBOXAMIDE DERIVATIVES AS JAK-2 MODULATORS | EXELIXIS, INC. (US) | 2008-04-10 | — | — | WO | disclosed |