Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 9/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2735383 | 1.00 | TOP2A (0.42) | TOP2AHSP90AB1ALDH1A1KMT2AMEN1 | |
| SCHEMBL13300431 | 0.92 | TOP2A (0.40) | TOP2AHSP90AB1ALDH1A1KMT2AMEN1 | |
| SCHEMBL216162 | 0.91 | ALDH1A1 (0.39) | ALDH1A1KMT2AMEN1HPGDCYP1A2 | |
| SCHEMBL213406 | 0.87 | TOP2A (0.44) | TOP2AALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL3984920 | 0.85 | IDO1 (0.35) | TOP2AALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL4109979 | 0.85 | ALDH1A1 (0.44) | ALDH1A1KMT2AMEN1HPGDCYP1A2 | |
| SCHEMBL2735449 | 0.85 | ALDH1A1 (0.41) | TOP2AHSP90AB1ALDH1A1KMT2AMEN1 | |
| SCHEMBL214824 | 0.85 | ALDH1A1 (0.41) | TOP2AHSP90AB1ALDH1A1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL213801 | 0.84 | ALDH1A1 (0.40) | TOP2AHSP90AB1ALDH1A1KMT2AMEN1 | |
| SCHEMBL2735386 | 0.84 | ALDH1A1 (0.45) | ALDH1A1KMT2AMEN1HPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088767-B2 | JAK-2 modulators and methods of use | EXELIXIS, INC. (US) | 2012-01-03 | — | — | US | disclosed |
| US-8088767-B2 | JAK-2 modulators and methods of use | EXELIXIS, INC. (US) | 2012-01-03 | — | — | US | disclosed |
| US-8088767-B2 | JAK-2 modulators and methods of use | EXELIXIS, INC. (US) | 2012-01-03 | — | — | US | disclosed |
| EP-2061768-A2 | IMIDAZOLE-4,5-DICARBOXAMIDE DERIVATIVES AS JAK-2 MODULATORS | Exelixis, Inc. (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008042282-A2 | IMIDAZOLE-4, 5-DICARBOXAMIDE DERIVATIVES AS JAK-2 MODULATORS | EXELIXIS, INC. (US) | 2008-04-10 | — | — | WO | disclosed |
| WO-2008042282-A2 | IMIDAZOLE-4, 5-DICARBOXAMIDE DERIVATIVES AS JAK-2 MODULATORS | EXELIXIS, INC. (US) | 2008-04-10 | — | — | WO | disclosed |