Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 19/20 | 0.69 |
| ▸ | ADRB1 | P08588 | 15/20 | 0.69 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.69 |
| ▸ | HTR2A | P28223 | 2/20 | 0.69 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.69 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.69 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.69 |
| ▸ | MLNR | O43193 | 1/20 | 0.69 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.69 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.69 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.69 |
| ▸ | DRD1 | P21728 | 1/20 | 0.69 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.69 |
| ▸ | MC3R | P41968 | 1/20 | 0.69 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.69 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.69 |
| ▸ | GHSR | Q92847 | 1/20 | 0.69 |
| ▸ | ADRB3 | P13945 | 14/20 | 0.65 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21587434 | 0.89 | ADRB2 (0.56) | ADRB2ADRB1SLC6A2HTR2ASLC6A4 | |
| SCHEMBL21024234 | 0.87 | ADRB2 (0.77) | ADRB2ADRB1SLC6A2HTR2ASLC6A4 | |
| SCHEMBL26262583 | 0.85 | ADRB2 (0.66) | ADRB2ADRB1SLC6A2HTR2ASLC6A4 | |
| SCHEMBL17031690 | 0.85 | ADRB2 (0.72) | ADRB2ADRB1SLC6A2HTR2ASLC6A4 | |
| SCHEMBL3982300 | 0.84 | ADRB2 (0.67) | ADRB2ADRB1SLC6A2HTR2ASLC6A4 | |
| SCHEMBL17031688 | 0.83 | ADRB2 (0.84) | ADRB2ADRB1SLC6A2HTR2ASLC6A4 | |
| SCHEMBL12039344 | 0.83 | ADRB2 (0.75) | ADRB2ADRB1SLC6A2HTR2ASLC6A4 | |
| SCHEMBL3979584 | 0.82 | ADRB2 (0.77) | ADRB2ADRB1SLC6A2HTR2ASLC6A4 | |
| SCHEMBL928189 | 0.82 | ADRB2 (1.00) | ADRB2ADRB1SLC6A2HTR2ASLC6A4 | |
| Vilanterol SCHEMBL142630 | 0.82 | ADRB2 (1.00) | ADRB2ADRB1SLC6A2HTR2ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3578169-A1 | PHARMACEUTICAL FORMULATIONS COMPRISING 4-{(1 R)-2-[(6-{2-[(2,6-DICHLOROBENZYL)OXY]ETHOXY}HEXYL)AMINO]-1-HYDROXYETHYL}-2-(HYDROXYMETHYL)PHENOL | GLAXO GROUP LIMITED (GB) | 2019-12-11 | — | — | EP | disclosed |