Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | ATR | Q13535 | 5/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.44 |
| ▸ | MTOR | P42345 | 13/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 7/20 | 0.41 |
| ▸ | RPTOR | Q8N122 | 6/20 | 0.41 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.41 |
| ▸ | RICTOR | Q6R327 | 5/20 | 0.41 |
| ▸ | MAPKAP1 | Q9BPZ7 | 5/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.41 |
| ▸ | ATRIP | Q8WXE1 | 2/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21588289 | 1.00 | AKR1C3 (0.46) | AKR1C3ATRPIK3CAPIK3CDMTOR | |
| SCHEMBL21588307 | 1.00 | AKR1C3 (0.46) | AKR1C3ATRPIK3CAPIK3CDMTOR | |
| SCHEMBL15142035 | 0.82 | ATR (0.46) | ATRPIK3CAPIK3CDMTORPIK3R1 | |
| SCHEMBL15141830 | 0.82 | ATR (0.46) | ATRPIK3CAPIK3CDMTORPIK3R1 | |
| SCHEMBL15141832 | 0.82 | ATR (0.46) | ATRPIK3CAPIK3CDMTORPIK3R1 | |
| SCHEMBL20605987 | 0.81 | MTOR (0.46) | PIK3CAMTORPIK3R1RPTORMLST8 | |
| SCHEMBL20606347 | 0.81 | MTOR (0.46) | PIK3CAMTORPIK3R1RPTORMLST8 | |
| SCHEMBL20605988 | 0.81 | MTOR (0.46) | PIK3CAMTORPIK3R1RPTORMLST8 | |
| SCHEMBL23023563 | 0.80 | ATR (0.43) | ATRPIK3CAPIK3CDMTORPIK3R1 | |
| SCHEMBL25359631 | 0.79 | MTOR (0.43) | ATRPIK3CAPIK3CDMTORPIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019233883-A1 | TETRAHYDROBENZOFURO[2,3-C]PYRIDINE AND BETA-CARBOLINE COMPOUNDS FOR THE TREATMENT, ALLEVIATION OR PREVENTION OF DISORDERS ASSOCIATED WITH TAU AGGREGATES | AC IMMUNE SA (CH) | 2019-12-12 | — | — | WO | disclosed |