SCHEMBL21588977

SCHEMBL21588977

Cc1nn(CC(F)(F)F)cc1Nc1ncc(F)c(NCc2ccc(S(N)(=O)=O)cc2)n1

nearest known ligand 0.84

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LRRK2 Q5S007 7/20 0.84
TBK1 Q9UHD2 4/20 0.84
IKBKE Q14164 3/20 0.84
MKNK2 Q9HBH9 3/20 0.84
CSF1R P07333 2/20 0.84
ULK3 Q6PHR2 2/20 0.84
STK17B O94768 1/20 0.84
AAK1 Q2M2I8 1/20 0.84
NUAK2 Q9H093 1/20 0.84
PI4KB Q9UBF8 1/20 0.84
MARK4 Q96L34 2/20 0.47
STK17A Q9UEE5 2/20 0.46
MYLK2 Q9H1R3 2/20 0.43
NIM1K Q8IY84 1/20 0.43
PTK2 Q05397 2/20 0.43
CYP1A2 P05177 2/20 0.42
NTRK1 P04629 1/20 0.42
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA9 Q16790 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21588800 0.92 LRRK2 (0.85) LRRK2TBK1IKBKEMKNK2CSF1R
SCHEMBL21588805 0.91 TBK1 (1.00) LRRK2TBK1IKBKEMKNK2CSF1R
SCHEMBL29710773 0.91 TBK1 (1.00) LRRK2TBK1IKBKEMKNK2CSF1R
SCHEMBL21588798 0.91 TBK1 (0.83) LRRK2TBK1IKBKEMKNK2CSF1R
SCHEMBL21588799 0.91 LRRK2 (0.83) LRRK2TBK1IKBKEMKNK2CSF1R
SCHEMBL21588815 0.91 LRRK2 (0.83) LRRK2TBK1IKBKEMKNK2CSF1R
SCHEMBL21588801 0.89 LRRK2 (0.80) LRRK2TBK1IKBKEMKNK2CSF1R
SCHEMBL21588827 0.88 TBK1 (0.79) LRRK2TBK1IKBKEMKNK2CSF1R
SCHEMBL21588828 0.88 TBK1 (1.00) LRRK2TBK1IKBKEMKNK2CSF1R
SCHEMBL21588975 0.84 CSF1R (1.00) LRRK2TBK1IKBKEMKNK2CSF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019233891-A1 TBK1 INHIBITOR COMPOUNDS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2019-12-12 WO disclosed