Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21589235 | 0.83 | MAPT (0.49) | MAPTL3MBTL1RAB9ANPC1HTT | |
| SCHEMBL8204958 | 0.73 | MAPT (0.55) | MAPTL3MBTL1RAB9ANPC1HTT | |
| SCHEMBL21589175 | 0.71 | MAPT (0.46) | MAPTL3MBTL1RAB9ANPC1HTT | |
| SCHEMBL9187424 | 0.70 | MAPT (0.59) | MAPTL3MBTL1RAB9ANPC1HTT | |
| Iodide SCHEMBL10843424 | 0.68 | MAPT (0.57) | MAPTL3MBTL1RAB9ANPC1HTT | |
| SCHEMBL16363728 | 0.68 | MAPT (0.57) | MAPTL3MBTL1RAB9ANPC1HTT | |
| SCHEMBL1435606 | 0.68 | MAPT (0.57) | MAPTL3MBTL1RAB9ANPC1HTT | |
| SCHEMBL8205262 | 0.68 | MAPT (0.57) | MAPTL3MBTL1RAB9ANPC1HTT | |
| SCHEMBL10604301 | 0.65 | MAPT (0.57) | MAPTL3MBTL1RAB9ANPC1HTT | |
| SCHEMBL27953291 | 0.65 | MAPT (0.41) | MAPTL3MBTL1RAB9ANPC1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019232665-A1 | THIOLIZED INDOLIZINE COMPOUND HAVING ANTICANCER ACTIVITY AND DERIVATIVE THEREOF | 广东药科大学 (CN) | 2019-12-12 | — | — | WO | disclosed |