Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 6/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL21640494 | 0.94 | USP2 (0.54) | KDM4EALDH1A1LMNAHPGDHTT | |
| SCHEMBL8394609 | 0.76 | HRH3 (0.56) | KDM4EHTTSMN1; SMN2KMT2A | |
| SCHEMBL8397665 | 0.76 | HRH3 (0.56) | KDM4EHTTSMN1; SMN2KMT2A | |
| SCHEMBL8393806 | 0.76 | HRH3 (0.56) | KDM4EHTTSMN1; SMN2KMT2A | |
| SCHEMBL3249887 | 0.76 | HRH3 (0.56) | KDM4EHTTSMN1; SMN2KMT2A | |
| SCHEMBL8392658 | 0.76 | HRH3 (0.56) | KDM4EHTTSMN1; SMN2KMT2A | |
| SCHEMBL24575950 | 0.76 | HPGD (0.72) | LMNAHPGDHTTSMN1; SMN2USP2 | |
| SCHEMBL15492723 | 0.75 | SMN1; SMN2 (0.57) | LMNAHPGDHTTSMN1; SMN2USP2 | |
| SCHEMBL6061649 | 0.74 | SMN1; SMN2 (0.66) | KDM4ELMNAHPGDHTTSMN1; SMN2 | |
| SCHEMBL8392252 | 0.74 | TPSAB1 (0.54) | KDM4EALDH1A1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110183974-A1 | 1,2,4-OXADIAZOLE SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS | INSTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI (IT) | 2011-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110183974-A1 | 1,2,4-OXADIAZOLE SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS | SHH, SMO, GLI1 | KDM4E 2888/4885ALDH1A1 663/4885LMNA 4797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.