Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 4/20 | 0.40 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.40 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | LGMN | Q99538 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | S100B | P04271 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21590278 | 1.00 | PBRM1 (0.40) | PBRM1SMARCA2SMARCA4ARCDK1 | |
| SCHEMBL21590360 | 1.00 | PBRM1 (0.40) | PBRM1SMARCA2SMARCA4ARCDK1 | |
| SCHEMBL13957107 | 0.88 | KDM4E (0.40) | PBRM1SMARCA2SMARCA4ARCDK1 | |
| SCHEMBL27645356 | 0.81 | LGMN (0.41) | PBRM1SMARCA2SMARCA4ARCDK1 | |
| SCHEMBL27009114 | 0.78 | F10 (0.39) | ARGAAMAPTALDH1A1LMNA | |
| SCHEMBL27009296 | 0.78 | F10 (0.39) | ARGAAMAPTALDH1A1LMNA | |
| SCHEMBL28402999 | 0.78 | AR (0.56) | ARMEN1KMT2AALDH1A1ALOX15 | |
| SCHEMBL5091948 | 0.78 | GAA (0.60) | LGMNGAAMEN1KMT2AMAPT | |
| SCHEMBL3436023 | 0.77 | GAA (0.59) | PBRM1SMARCA2SMARCA4ARCDK1 | |
| SCHEMBL3436206 | 0.77 | GAA (0.59) | PBRM1SMARCA2SMARCA4ARCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |