Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 14/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28502006 | 0.88 | MAP4K1 (0.44) | WDR5CHEK1MAP4K1 | |
| SCHEMBL28514984 | 0.88 | FGFR1 (0.38) | WDR5CHEK1MAP4K1 | |
| SCHEMBL28507697 | 0.85 | CHEK1 (0.48) | CHEK1MAP4K1 | |
| SCHEMBL15599358 | 0.84 | PIK3CA (0.51) | BACE1 | |
| SCHEMBL28499816 | 0.83 | NR1H2 (0.43) | — | |
| SCHEMBL31553241 | 0.80 | PAK1 (0.46) | FLT3MAP4K1 | |
| SCHEMBL17282548 | 0.80 | SMPD3 (0.48) | MAP4K1 | |
| SCHEMBL22971783 | 0.79 | MAP3K11 (0.51) | FLT3MAPK1MAP4K1 | |
| SCHEMBL28506918 | 0.79 | MAP4K1 (0.39) | MAP4K1 | |
| SCHEMBL28500725 | 0.78 | MAP4K1 (0.42) | WDR5CHEK1MAP4K1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |