Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 4/20 | 0.48 |
| ▸ | MAP4K1 | Q92918 | 15/20 | 0.45 |
| ▸ | IL2 | P60568 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28506162 | 0.88 | CHEK1 (0.48) | CHEK1MAP4K1IL2LCKMAP4K3 | |
| SCHEMBL28502006 | 0.88 | MAP4K1 (0.44) | CHEK1MAP4K1IL2 | |
| SCHEMBL28514984 | 0.87 | FGFR1 (0.38) | CHEK1MAP4K1LCKMAP4K3 | |
| SCHEMBL22971783 | 0.86 | MAP3K11 (0.51) | MAP4K1LCK | |
| SCHEMBL21590168 | 0.85 | WDR5 (0.41) | CHEK1MAP4K1 | |
| SCHEMBL28506918 | 0.84 | MAP4K1 (0.39) | MAP4K1IL2LCKMAP4K3FYN | |
| SCHEMBL21590350 | 0.83 | CHEK1 (0.45) | CHEK1MAP4K1IL2LCKMAP4K3 | |
| SCHEMBL31553241 | 0.83 | PAK1 (0.46) | MAP4K1 | |
| SCHEMBL28499816 | 0.82 | NR1H2 (0.43) | — | |
| SCHEMBL719094 | 0.80 | GSK3B (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |