Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 20/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23150855 | 1.00 | GABRA1 (0.42) | GABRA1 | |
| SCHEMBL23150862 | 1.00 | GABRA1 (0.42) | GABRA1 | |
| SCHEMBL21590948 | 0.95 | GABRA1 (0.42) | GABRA1 | |
| SCHEMBL21590790 | 0.90 | GABRA1 (0.47) | GABRA1 | |
| SCHEMBL30694889 | 0.90 | GABRA1 (0.41) | GABRA1 | |
| SCHEMBL21590863 | 0.90 | GABRA1 (0.47) | GABRA1 | |
| SCHEMBL21590869 | 0.90 | GABRA1 (0.47) | GABRA1 | |
| SCHEMBL30694894 | 0.90 | GABRA1 (0.41) | GABRA1 | |
| SCHEMBL21590698 | 0.89 | GABRA1 (0.45) | GABRA1 | |
| SCHEMBL21590751 | 0.89 | GABRA1 (0.45) | GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3807269-A1 | NEW ISOXAZOLYL ETHER DERIVATIVES AS GABA A ALPHA5 PAM | F. Hoffmann-La Roche AG (CH) | 2021-04-21 | — | — | EP | disclosed |
| WO-2019238633-A1 | NEW ISOXAZOLYL ETHER DERIVATIVES AS GABA A ALPHA5 PAM | F. HOFFMANN-LA ROCHE AG (CH) | 2019-12-19 | — | — | WO | disclosed |