SCHEMBL21592298

SCHEMBL21592298

COc1cc2ncn(CCCN(Cc3ccncc3)Cc3coc4c(ccc5ccccc54)c3=O)c2cc1OC

nearest known ligand 0.36

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ KCNA5 P22460 4/20 0.36
▸ MAOA P21397 4/20 0.34
▸ BCHE P06276 1/20 0.34
▸ ACHE P22303 1/20 0.34
▸ ALDH1A1 P00352 2/20 0.33
▸ NPSR1 Q6W5P4 2/20 0.33
▸ RXFP1 Q9HBX9 1/20 0.33
▸ KCNJ5 P48544 1/20 0.33
▸ KCNJ3 P48549 1/20 0.33
▸ PLK1 P53350 1/20 0.33
▸ CYP11B1 P15538 1/20 0.33
▸ CYP11B2 P19099 1/20 0.33
▸ SIRT2 Q8IXJ6 1/20 0.33
▸ MAOB P27338 2/20 0.33
▸ PDE10A Q9Y233 2/20 0.33
▸ KDM4E B2RXH2 1/20 0.32
▸ CYP1A2 P05177 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21592291 0.88 KMT2A (0.35) KCNA5ALDH1A1KCNJ5KCNJ3CYP11B1
SCHEMBL21592282 0.85 CYP11B1 (0.40) KCNA5BCHEACHEKCNJ5KCNJ3
SCHEMBL21592285 0.84 KCNA5 (0.36) KCNA5ALDH1A1KCNJ5KCNJ3CYP11B1
SCHEMBL21591545 0.84 SMN1; SMN2 (0.33) KCNA5ALDH1A1NPSR1KDM4E
SCHEMBL21592278 0.80 POLB (0.38) KCNA5ALDH1A1KCNJ5KCNJ3CYP11B1
SCHEMBL21591444 0.78 CYP11B1 (0.42) ALDH1A1CYP11B1CYP11B2KDM4E
SCHEMBL21591551 0.78 MEN1 (0.33) NPSR1KDM4E
SCHEMBL21591434 0.77 CYP11B1 (0.39) ALDH1A1CYP11B1CYP11B2KDM4E
SCHEMBL21591431 0.76 CYP11B1 (0.48) ALDH1A1NPSR1CYP11B1CYP11B2MAOB
SCHEMBL31361796 0.74 FNTA (0.33) ALDH1A1NPSR1CYP11B1CYP11B2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220402898-A1 MODULATORS OF STIMULATOR OF INTERFERON GENES (STING) Ryvu Therapeutics S.A. (PL) 2022-12-22 — — US disclosed
WO-2019238786-A1 MODULATORS OF STIMULATOR OF INTERFERON GENES (STING) Ryvu Therapeutics S.A. (PL) 2019-12-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220402898-A1 MODULATORS OF STIMULATOR OF INTERFERON GENES (STING) STING1, IRF3, CGAS KCNA5 2592/4885MAOA 747/4885BCHE 4622/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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