Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 5/20 | 0.60 |
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.56 |
| ▸ | TNIK | Q9UKE5 | 8/20 | 0.54 |
| ▸ | IL2 | P60568 | 1/20 | 0.54 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592426 | 0.91 | MAP3K11 (0.71) | MAP3K11MAP4K1TNIKIL2IGF1R | |
| SCHEMBL21592545 | 0.87 | MAP3K11 (0.66) | MAP3K11MAP4K1TNIKIL2IGF1R | |
| SCHEMBL21592465 | 0.87 | MAP3K11 (0.66) | MAP3K11MAP4K1TNIKIL2IGF1R | |
| SCHEMBL21592500 | 0.87 | MAP3K11 (0.60) | MAP3K11MAP4K1TNIKIL2IGF1R | |
| SCHEMBL21592469 | 0.87 | MAP4K1 (0.63) | MAP3K11MAP4K1TNIKIL2IGF1R | |
| SCHEMBL21592558 | 0.87 | MAP3K11 (0.63) | MAP3K11MAP4K1TNIKIL2IGF1R | |
| SCHEMBL21592498 | 0.86 | MAP3K11 (0.65) | MAP3K11MAP4K1TNIKIL2IGF1R | |
| SCHEMBL21592572 | 0.86 | MAP3K11 (0.64) | MAP3K11MAP4K1TNIKIL2IGF1R | |
| SCHEMBL21592623 | 0.85 | MAP4K1 (0.60) | MAP3K11MAP4K1TNIKIL2CLK1 | |
| SCHEMBL21592544 | 0.85 | MAP4K1 (0.67) | MAP3K11MAP4K1CLK1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |